Guide for the Care and Use of Laboratory Animals - Office of ...

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appendixCStatement of TaskThe use of laboratory animals for biomedical research, testing andeducation is guided by the principles of the Three Rs, replacementof animals where acceptable non-animal models exist, reduction inthe number of animals to the fewest needed to obtain statistically significantdata, and refinement of animal care and use to minimize pain anddistress and to enhance animal well-being. The Guide for the Care andUse of Laboratory Animals has been a critical international publication thatprovides information to scientists, veterinarians and animal care personnelwhen the decision has been made that animal use is necessary. A committeewill update the 1996 version of the Guide for the Care and Use of LaboratoryAnimals (the Guide) to reflect new scientific information related to theissues already covered in the Guide, and to add discussion and guidanceon new topics of laboratory animal care and use related to contemporaryanimal research programs.The committee will review the scientific literature published since therelease of the 1996 Guide and determine whether the information in theGuide concurs with current scientific evidence. The committee will alsoreview the literature on new technologies related to laboratory animal careand use and determine where new guidance is necessary to ensure thebest scientific outcomes and optimal animal welfare. The committee willalso take into consideration all materials and discussions provided to it,including those submitted to NIH in response to the Request for InformationNOT-OD-O6-011 that requested information related to the need toupdate the Guide. Where scientifically warranted, the guidance and recommendationsof the 1996 Guide will be changed to reflect new scientific201
202 GUIdE FOR ThE CARE ANd USE OF LAbORATORy ANIMALSevidence, while maintaining the performance standards of the 1996 Guide.The committee will ensure that any recommendations in the Guide will beconsistent with current Public Health Service Policy, the Animal WelfareRegulations, and the most recent Report of the American Veterinary MedicalAssociation Panel on Euthanasia.In addition to the published report, the updated Guide will be postedon the Internet in a pdf or equivalent format such that users will be able tosearch the entire document at one time.
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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Page 226 and 227: appendixBU.S. Government Principles
Page 230 and 231: appendixDAbout the AuthorsJanet C.
Page 232 and 233: APPENdIX d: AbOUT ThE AUThORS 205of
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Page 236 and 237: IndexAAcclimation and adaptation, 1
Page 238 and 239: INdEX 211Behavioral and social mana
Page 240 and 241: INdEX 213Disinfection, 20, 51, 52,
Page 242 and 243: INdEX 215Hydrogen peroxide, 72Hygie
Page 244 and 245: INdEXrecommended reading, 169-170re
Page 246 and 247: INdEX21pain and distress, 121-122re
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