Guide for the Care and Use of Laboratory Animals - Office of ...

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COMMITTEE FOR THE UPDATE OF THE GUIDE FOR THE CAREAND USE OF LAbORATORy ANIMALSMembersJanet C. Garber (Chair), Garber ConsultingR. Wayne barbee, Virginia Commonwealth UniversityJoseph T. bielitzki, University of Central FloridaLeigh Ann Clayton, National Aquarium, BaltimoreJohn C. Donovan, BioResources, Inc.Coenraad F. M. Hendriksen, Netherlands Vaccine Institute, Bilthoven,The Netherlands (until March 2009)Dennis F. Kohn, Columbia University (retired)Neil S. Lipman, Memorial Sloan-Kettering Cancer Center and WeillCornell Medical CollegePaul A. Locke, Johns Hopkins Bloomberg School of Public HealthJohn Melcher, U.S. Senate (retired)Fred W. Quimby, Rockefeller University (retired)Patricia V. Turner, University of Guelph, CanadaGeoffrey A. Wood, University of Guelph, CanadaHanno Würbel, Justus Liebig University of Giessen, GermanyStaffLida Anestidou, Study DirectorFrances Sharples, Acting DirectorKathleen beil, Administrative CoordinatorCameron H. Fletcher, Senior EditorRuth Crossgrove, Senior EditorRadiah Rose, Manager of Editorial ProjectsRhonda Haycraft, Senior Project AssistantJoanne Zurlo, Director (until April 2010)
MembersINSTITUTE FOR LAbORATORy ANIMAL RESEARCH COUNCILStephen W. barthold (Chair), Center for Comparative Medicine,University of California-DavisKathryn A. bayne, Association for Assessment and Accreditation ofLaboratory Animal Care International, Frederick, MarylandMyrtle A. Davis, National Cancer Institute, National Institutes of Health,Bethesda, MarylandJeffrey I. Everitt, Comparative Medicine and Investigator Support,GlaxoSmithKline Research and Development, Research Triangle Park,North Carolina (until June 2010)James G. Fox, Division of Comparative Medicine, Massachusetts Instituteof Technology, CambridgeNelson L. Garnett, Laboratory Animal Care and Use Programs,Dickerson, MDEstelle b. Gauda, Johns Hopkins University School of Medicine, JohnsHopkins Hospital, Baltimore, Maryland (until June 2010)Joseph W. Kemnitz, Institute for Clinical and Translational Research andDepartment of Physiology, University of Wisconsin-MadisonJudy A. MacArthur Clark, Animals in Scientific Procedures Inspectorate,Home Office, London, United KingdomMartha K. McClintock, Institute for Mind and Biology, University ofChicago, IllinoisLeticia V. Medina, Animal Welfare and Compliance, Abbott Laboratories,Abbott Park, IllinoisTimo Olavi Nevalainen, National Laboratory Animal Center, University ofEastern Finland, Kuopio, Finlandbernard E. Rollin, Department of Animal Sciences, Colorado StateUniversity, Fort CollinsAbigail L. Smith, School of Veterinary Medicine, University ofPennsylvania, Philadelphia (until June 2010)Stephen A. Smith, Department of Biomedical Sciences and Pathobiology,Virginia Polytechnic Institute and State University, BlacksburgJames E. Womack, Department of Veterinary Pathology, Texas A&MUniversity, College Station (until June 2010)i
Page 2 and 3: GUIDEFOR THE CARE AND USE OFLABORAT
Page 4: The National Academy of Sciences is
Page 9 and 10: INSTITUTE FOR LAbORATORy ANIMAL RES
Page 12 and 13: ReviewersThis eighth edition of the
Page 14 and 15: PrefaceThe purpose of the Guide for
Page 16: PREFACExwho soon recognized that th
Page 19 and 20: xiiiOVERVIEWing the growing role of
Page 22 and 23: Contents1 KEy CONCEPTS 1Applicabili
Page 24 and 25: CONTENTSxxiiiAquatic Management, 84
Page 26: CONTENTSxxSpecies-Specific Referenc
Page 29 and 30: 2 GUIdE FOR ThE CARE ANd USE OF LAb
Page 38 and 39: 2Animal Care and Use ProgramThe pro
Page 40 and 41: ANIMAL CARE ANd USE PROGRAM 13of li
Page 42 and 43: ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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156 AddENdUM4. Page 32. Original se
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Appendices
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appendixBU.S. Government Principles
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appendixCStatement of TaskThe use o
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appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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