Guide for the Care and Use of Laboratory Animals - Office of ...

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APPENdIX d: AbOUT ThE AUThORS 205of Laboratory Animal Science. He began his career in the pharmaceuticalindustry in 1994 as Senior Director of Worldwide Laboratory AnimalResources for Rhone Poulenc-Rorer Pharmaceuticals, leading to his positionas Vice President of Laboratory Animal Science and Welfare for AventisPharmaceuticals in 1999. In 2001 he moved to Wyeth Pharmaceuticalswhere he was Vice President of BioResources until his retirement in 2007.During his career, Dr. Donovan served in numerous professional leadershippositions including President of ACLAM and President of the Board ofDirectors of the Pennsylvania Society for Biomedical Research (PSBR). Healso served on several boards including those of the National Associationfor Biomedical Research, ACLAM, PSBR, and the New Jersey Association forBiomedical Research.Dennis F. Kohn, DVM, PhD, is Professor Emeritus of Clinical ComparativePathology at Columbia University. He received his DVM from Ohio StateUniversity and a doctorate in Medical Microbiology from West VirginiaUniversity. He is board certified by the American College of LaboratoryAnimal Medicine. He has directed laboratory animal resource/comparativemedicine programs at West Virginia University Medical Center, Universityof Texas Medical School at Houston, and the Health Sciences Division,Columbia University. His research interests have dealt primarily with thepathogenicity of Mycoplasma pulmonis in the respiratory tract of laboratoryrats, and the experimental pathology induced within the CNS and joints ofrats inoculated with M. pulmonis. He is a past president of the AmericanCollege of Laboratory Animal Medicine and the American Society of LaboratoryAnimal Practitioners, and as chair of a number of American Associationof Laboratory Animal Science committees. He has served as a Councilmember of AAALAC-International, as a member of the 1986 American VeterinaryMedical Association’s Panel on Euthanasia, and the 1996 Instituteof Laboratory Animal Resources’ committee to revise the Guide.Neil S. Lipman, VMD, is Director of the Center of Comparative Medicineand Pathology serving the Memorial Sloan-Kettering Cancer Center (MSKCC)and the Weill Medical College of Cornell University and is Professor of VeterinaryMedicine in Pathology and Laboratory Medicine at Weill Cornellas well as a Laboratory Member at the Sloan-Kettering Institute at MSKCC.Dr. Lipman is a Diplomate of the American College of Laboratory AnimalMedicine with over 25 years’ experience in laboratory animal medicineand science. Dr. Lipman has expertise in vivarium design, engineering, andoperations, having designed over 1.5 million gross square feet of vivariumspace and overseen the operation of a number of major academic animalresource programs. His research interests are principally translational andinclude development and analysis of new technologies especially with
206 GUIdE FOR ThE CARE ANd USE OF LAbORATORy ANIMALSrespect to rodent housing systems and monoclonal antibody production,the characterization of various animal models, understanding the etiopathogenesisof endocrinologic disorders affecting laboratory animal species, anddevelopment and analysis of novel therapeutic strategies. Throughout hiscareer, Dr. Lipman has been extensively involved in the postgraduate trainingof laboratory animal specialists.Paul Locke, MPH, JD, DrPH, an environmental health scientist and attorney,is Associate Professor at the Johns Hopkins University Bloomberg Schoolof Public Health in the Department of Environmental Health Sciences,Division of Toxicology. He holds an MPH from Yale University School ofMedicine, a DrPH from the Johns Hopkins University Bloomberg Schoolof Public Health and a JD degree from Vanderbilt University School ofLaw. Prior to joining the Department of Environmental Health, he was theDeputy Director of the Pew Environmental Health Commission and theDirector of the Center for Public Health and Law at the Environmental LawInstitute. Dr. Locke’s research and practice focus on how decision makersuse environmental health science and toxicology in regulation and policymaking and how environmental health sciences influence the policy-makingprocess. His areas of study include alternatives to animal testing inbiomedical research, with particular emphasis on toxicity testing. He alsomaintains an active research program in radiation studies and radiation protectionpolicy. Dr. Locke directs the Doctor of Public Health degree programin the Department of Environmental Health Sciences and is co-director ofthe Johns Hopkins certificate program in Humane Science and Toxicology.From 2004 until 2009 he was a member of the National Academy of SciencesNuclear and Radiation Studies Board, and has served on five NationalAcademy of Sciences/National Research Council expert committees. He isadmitted to practice law before the bars of the states of New York and NewJersey, the District of Columbia, the United States Court of Appeals for theSecond Circuit and the United States Supreme Court.The Honorable John Melcher, DVM, a graduate of the College of VeterinaryMedicine of the Iowa State University, was a practicing veterinarian inthe state of Montana until 1969, in which year he was elected to the U.S.House of Representatives. He served as a Congressman for 8 years and asa Senator for 12 years. In both the House and the Senate, Senator Melcherwas noted for his interest in agriculture, protection of public lands, notablyForest Service and Bureau of Land Management lands, and animal welfareand animal health protections. In 1984 he contributed to the Animal WelfareAct with an amendment requiring consideration of the psychologicalwell being of primates used in medical research. After retiring from Congress,Senator Melcher established a second career as a consultant for the
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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Page 226 and 227: appendixBU.S. Government Principles
Page 228 and 229: appendixCStatement of TaskThe use o
Page 230 and 231: appendixDAbout the AuthorsJanet C.
Page 234 and 235: APPENdIX d: AbOUT ThE AUThORS20Amer
Page 236 and 237: IndexAAcclimation and adaptation, 1
Page 238 and 239: INdEX 211Behavioral and social mana
Page 240 and 241: INdEX 213Disinfection, 20, 51, 52,
Page 242 and 243: INdEX 215Hydrogen peroxide, 72Hygie
Page 244 and 245: INdEXrecommended reading, 169-170re
Page 246 and 247: INdEX21pain and distress, 121-122re
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