Guide for the Care and Use of Laboratory Animals - Office of ...

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INdEX 215Hydrogen peroxide, 72Hygiene, personal, 18, 19, 20IIdentification of animals, 75, 87Illumination/lighting, 47-49, 81, 141Imaging facilities, 146-147Immunization, 22Immunodeficient animals, 21, 28, 66, 145Infectious agents (see Biologic agents andhazardsInfectious disease research, 27Inspection of facilities and equipment, 34Institute for Laboratory Animal Resources(ILAR), 2, 16Institutional Animal Care and UseCommitteeagricultural animals, 32-33animal care and use programs and, 6,11, 13collaborating institutions, 15endpoint considerations, 27-28field investigations, 32food and fluid regulation, 30-31investigating and reporting animalwelfare concerns, 23membership and function of committee,17, 24-25multiple survival surgical procedures, 30non-pharmaceutical-grade chemicals orsubstances, 31occupational health and safety and, 17physical restraint, 29-30program management and, 13, 14-15protocol review, 25-26recommended reading, 169-170special considerations during reviewprocess, 27-33surgery and, 115-118surgical procedures, 30training and education, 15unexpected outcomes, 28-29Institutional official, 13-14, 17, 23, 24, 25,30, 35International Air Transport Association, 107International Committee on StandardizedGenetic Nomenclature for Mice, 77Invertebrate animals, 2Irradiation facilities, 157-158LLaboratory Animal Welfare and TrainingExchange, 16Latex toxicity, 84Laws, regulations, and policies (see alsoAnimal Welfare Act; Animal WelfareRegulations; Public Health ServicePolicy; other specific acts and policies)recommended reading, 168training in, 17Lighting (see Ilumination/lighting)Lymphocytic choriomeningitis virus, 113MMacacine herpesvirus, 23, 112Macaques, 23, 112Macroenvironmentaquatic species, 77-78, 86defined, 42terrestrial species, 42Management of animals (see Behavioraland social management; Husbandry;Population management)aquatic species, 84-88medical, 114recommended reading, 172-173terrestrial species, 63-77Mice (see also Rodents)acclimation, 111aggression in males, 53, 64anxiety studies, 53bedding and nesting materials, 52, 53,68breeding animals, 52caloric restriction, 67enrichment, 53, 54GMAs, 28, 68, 145-146housing, 53, 57, 145-146identification/nomenclature, 77illumination, 49, 137infections, 111, 112nude or hairless animals, 68recommended reading, 184-187,194-196social stress, 53space requirements, 57, 156specific pathogen-free mice, 145-146temperature and humidity, 43, 45toe-clipping, 75
216 INdEXMicroenvironment (primary enclosure)aquatic species, 77-78, 82-83defined, 42terrestrial species, 42, 50-52Midwest Plan Service, 33Monitoring and surveillancedisease prevention, 112-113facilities, equipment, and exposure, 19-20food and fluid intake, 31GMAs, 28intraoperative, 119postapproval, 33-34postoperative care, 119restrained animals, 29sanitation practices, 72-73Monkeys (see Nonhuman primates)Monoclonal antibody production, 27Moribund state, 28Mouse hepatitis virus, 112, 113Mycoplasma hyopneumoniae, 112NNational Institutes of Health, 19, 155National Research Council Committee onAnimal Nutrition, 65Necropsies, 21Nesting (see Bedding, nesting, andsubstrates)Neuromuscular blocking agents, 122-123Nocturnal animals, 48Noise and vibrationaquatic animals, 81-82control, 142, 143hearing protection for personnel, 22, 49terrestrial animals, 49-50Non-pharmaceutical-grade chemicals orsubstances, 31-32Nonhuman primatesacclimation, 111behavioral and social management, xviii,29, 53enrichment, 53, 67, 137environment, 43, 44, 45, 50, 139food and feeding, 67housing, xviii, 49, 111-112, 136illumination, 48infections, 23, 111-112infusion pumps, 29noise and vibration effects, 50personal protective equipment for staff,21-22recommended reading, 182-184, 194recordkeeping, 75-76restraint, 29space requirements, xviii, 56, 58-60, 61temperature and humidity, 43, 44, 45,140transport, 107ventilation, 47, 139veterinary care, 194zoonosis surveillance and, 23, 110Noroviruses, 113OOccupational health and safety programadministrative controls, 18animal housing systems, 19-20collaborative approach, 17, 21control and prevention strategies, 18engineering controls, 18, 19facility and equipment support, 19-20field studies or wildlife research, 18hazard identification and riskassessment, 18-19hazardous animal experimentation, 18,20-21hazardous material containment, 149hygiene, 18, 19, 20medical evaluation and preventivemedicine for personnel, 22-23monitoring, 19-20noise exposure, 22, 49personal protective equipment, 18, 20,21, 23, 109, 146, 148, 167-172recommended reading, 17, 19, 21,170-172regulations, 17, 18, 20, 21reporting requirements, 23-24responsibility, 18safety committee, 17-18, 21, 32security, 23training, 17, 18, 20, 21, 22, 24Organ or system failure research, 27Other animals, recommended reading,187-188Outdoor enclosures/habitats, 42, 44, 51,54-55, 68, 74, 81, 83, 118, 134, 135,139, 140Oversight (see also Institutional Animal Careand Use Committee)postapproval monitoring, 33-34
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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156 AddENdUM4. Page 32. Original se
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Appendices
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Page 226 and 227: appendixBU.S. Government Principles
Page 228 and 229: appendixCStatement of TaskThe use o
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Page 232 and 233: APPENdIX d: AbOUT ThE AUThORS 205of
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Page 236 and 237: IndexAAcclimation and adaptation, 1
Page 238 and 239: INdEX 211Behavioral and social mana
Page 240 and 241: INdEX 213Disinfection, 20, 51, 52,
Page 244 and 245: INdEXrecommended reading, 169-170re
Page 246 and 247: INdEX21pain and distress, 121-122re
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