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VETERINARy CARE12Morton CM, Reid J, Scott EM, Holton LL, Nolan AM. 2005. Application of a scaling model toestablish and validate an interval level pain scale for assessment of acute pain in dogs.Am J Vet Res 66:2154-2166.Murphey-Corb M, Martin LN, Rangan SRS, Baskin GB, Gormus BJ, Wolf RH, Andes WA, WestM, Montelaro RC. 1986. Isolation of an HTLV-III-related retrovirus from macaques withsimian AIDS and its possible origin in asymptomatic mangabeys. Nature 321:435-437.Murphy BL, Maynard JE, Krushak DH, Fields RM. 1971. Occurrence of a carrier state for herpesirustamarinus in marmosets. Appl Microbiol 21:50-52.Murrell JC, Johnson CB. 2006. Neurophysiological techniques to assess pain in animals. J VetPharmacol Ther 29:325-335.Nicklas W, Kraft V, Meyer B. 1993. Contamination of transplantable tumors, cell lines, andmonoclonal antibodies with rodent viruses. Lab Anim Sci 43:296-299.Niel L, Stewart SA, Weary DM. 2008. Effect of flow rate on aversion to gradual fill carbondioxide exposure in rats. Appl Animl Behav Sci 109:77-84.NRC [National Research Council]. 1991a. Barrier programs. In: Infectious Diseases of Miceand Rats. Washington: National Academy Press. p 17-20.NRC. 1991b. Individual disease agents and their effects on research. In: Infectious Diseases ofMice and Rats. Washington: National Academy Press. p 31-256.NRC. 1991c. Health surveillance programs. In: Infectious Diseases of Mice and Rats. Washington:National Academy Press. p 21-27.NRC. 1996. Rodents: Laboratory Animal Management. Washington: National AcademyPress.NRC. 2003. Guidelines for the Care and Use of Mammals in Neuroscience and BehavioralResearch. Washington: National Academies Press.NRC. 2006. Guidelines for the Humane Transportation of Research Animals. Washington:National Academies Press.NRC. 2008. Recognition and Alleviation of Distress in Laboratory Animals. Washington: NationalAcademies Press.NRC. 2009a. Recognition and Alleviation of Pain in Laboratory Animals. Washington: NationalAcademies Press.NRC. 2009b. Scientific and Humane Issues in the Use of Random Source Dogs and Cats inResearch. Washington: National Academies Press.Obernier JA, Baldwin RL. 2006. Establishing an appropriate period of acclimatization followingtransportation of laboratory animals. ILAR J 47:364-369.Otto G, Tolwani RJ. 2002. Use of microisolator caging in a risk-based mouse import and quarantineprogram: A retrospective study. Contemp Top Lab Anim Sci 41:20-27.Paul-Murphy J, Ludders JW, Robertson SA, Gaynor JS, Hellyer PW, Wong PL. 2004. The needfor a cross-species approach to the study of pain in animals. JAVMA 224:692-697.Pereira LJ, Lee GM, Wade KJ. 1990. The effect of surgical handwashing routines on the microbialcounts of operating room nurses. Am J Infect Control 18:354-364.Perret-Gentil M, Sinanan M, Dennis MB Jr, Horgan S, Weyhrich J, Anderson D, Hudda K. 1999.Videoendoscopy: An effective and efficient way to perform multiple visceral biopsies insmall animals. J Invest Surg 12:157-165.Perret-Gentil MI, Sinanan MN, Dennis MB Jr, Anderson DM, Pasieka HB, Weyhrich JT,Birkebak TA. 2000. Videoendoscopic techniques for collection of multiple serial intraabdominalbiopsy specimens in HIV-negative and HIV-positive pigtail macaques (Macacanemestrina). J Invest Surg 13:181-195.Peterson NC. 2008. From bench to cageside: Risk assessment for rodent pathogen contaminationof cells and biologics. ILAR J 49:310-315.Prasad SB, Gatmaitan R, O’Connell RC. 1978. Effect of a conditioning method on generalsafety test in guinea pigs. Lab Anim Sci 28:591-593.
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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Page 132 and 133: 4Veterinary CareVeterinary care is
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appendixBU.S. Government Principles
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appendixCStatement of TaskThe use o
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appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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