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VETERINARy CARE12Haines DC, Gorelick PL, Battles JK, Pike KM, Anderson RJ, Fox JG, Taylor NS, Shen Z, DewhirstFE, Anver MR, Ward JM. 1998. Inflammatory large bowel disease in immunodeficient ratsnaturally and experimentally infected with helicobacter bilis. Vet Pathol 35:202-208.Hancock RB, Lanz OI, Waldron DR, Duncan RB, Broadstone RV, Hendrix PK. 2005. Comparisonof postoperative pain after ovariohysterectomy by harmonic scalpel-assisted laparoscopycompared with median celiotomy and ligation in dogs. Vet Surg 34:273-282.Haskins SC, Eisele PH. 1997. Postoperative support and intensive care. In: Kohn DF, WixsonSK, White WJ, Benson GJ, eds. Anesthesia and Analgesia in Laboratory Animals. NewYork: Academic Press. p 381-382.Hawkins P. 2002. Recognizing and assessing pain, suffering and distress in laboratory animals:A survey of current practice in the UK with recommendations. Lab Anim 36:378-395.Hawkins P, Playle L, Golledge H, Leach M, Banzett R, Coenen A, Cooper J, Danneman P,Flecknell P, Kirkden R, Niel L, Raj M. 2006. Newcastle Consensus Report on CarbonDioxide Euthanasia of Laboratory Animals. Available at www.nc3rs.org.uk/downloaddoc.asp?id=416andpage=292andskin=0; accessed April 10, 2010.Hedenqvist P, Roughan JV, Flecknell PA. 2000. Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats. Lab Anim34:207-211.Heon H, Rousseau N, Montgomery J, Beauregard G, Choiniere M. 2006. Establishment ofan operating room committee and a training program to improve aseptic techniques forrodent and large animal surgery. JAALAS 45:58-62.Hirsch VM, Zack PM, Vogel AP, Johnson PR. 1991. Simian immunodeficiency virus infectionof macaques: End-stage disease is characterized by wide-spread distribution of proviralDNA in tissues. J Infect Dis 163:976-988.Hofmann LS. 1979. Preoperative and operative patient management. In: Wingfield WE, RawlingsCA, eds. Small Animal Surgery: An Atlas of Operative Technique. Philadelphia: WBSaunders. p 14-22.Holton LL, Scott EM, Nolan AM, Reid J, Welsh E, Flaherty D. 1998. Comparison of threemethods used for assessment of pain in dogs. JAVMA 212:61-66.Huerkamp MJR. 2002. Alcohol as a disinfectant for aseptic surgery of rodents: Crossing thethin blue line? Contemp Top Lab Anim Sci 41:10-12.Hughes HC, Lang CM. 1983. Control of pain in dogs and cats. In: Kitchell RL, Erickson HH,eds. Animal Pain: Perception and Alleviation. Bethesda, MD: American PhysiologicalSociety. p 207-216.Hunt RD, Melendez LV. 1966. Spontaneous herpes-T infection in the owl monkey (Aotustriirgatus). Pathol Vet 3:1-26.IATA [International Air Transport Association]. 2009. Live Animal Regulations (LAR), 36th ed.Available at www.iata.org/ps/publications/Pages/live-animals.aspx; accessed May 15,2010.IRAC [Interagency Research Animal Committee]. 1985. U.S. Government Principles for Utilizationand Care of Vertebrate Animals Used in Testing, Research, and Training. FederalRegister, May 20. Washington: Office of Science and Technology Policy.Jacoby RO, Lindsey R. 1998. Risks of infections among laboratory rats and mice at majorbiomedical research institutions. ILAR J 39:266-271.Joshi G, Ogunnaike B. 2005. Consequences of inadequate postoperative pain relief andchronic persistent postoperative pain. Anesthesiol Clin North America 23:21-36.Kagan KG. 1992a. Aseptic technique. Vet Tech 13:205-210.Kagan KG. 1992b. Care and sterilization of surgical equipment. Vet Tech 13:65-70.
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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Page 132 and 133: 4Veterinary CareVeterinary care is
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Page 140 and 141: VETERINARy CARE 113and serology. If
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Page 156 and 157: VETERINARy CARE12Morton CM, Reid J,
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18GUIdE FOR ThE CARE ANd USE OF LAb
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appendixBU.S. Government Principles
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appendixCStatement of TaskThe use o
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appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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