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AddendumGuide for the Care and Useof Laboratory AnimalsEighth EditionADDENDUM: LIST OF EDITORIAL CHANGESFROM THE PREPUbLICATION VERSION11. Page 22. Original sentence: “Personnel training should includeinformation on laboratory animal allergies, preventive control measuresand proper techniques for working with animals (Gordon etat. 1997; Schweitzer et al. 2003; Thulin et al. 2002).” “…earlyrecognition and reporting of allergy symptoms” was added to clarifythe guidance and reflect the cited references.2. Page 31. Original sentence: “They should therefore be used, whenavailable, for all animal-related procedures (NIH 2008; USDA1997b).” The NIH reference was removed because it applies onlyto the NIH intramural animal research program.3. Page 32. Original sentence: “Principal investigators conducting fieldresearch should be knowledgeable of relevant zoonotic diseases,associated safety issues, and, when working in an internationalenvironment, any local laws or regulations that apply.” Compliancewith laws and regulations applies to field investigations irrespectiveof location, so “when working in an international environment”and “local” were deleted.1Page numbers reflect placement of revisions in this report.155
156 AddENdUM4. Page 32. Original sentence: “Appropriate veterinary input is neededfor projects involving capture, individual identification, sedation,anesthesia, surgery, recovery, holding, transportation, release, oreuthanasia.” Beginning of sentence changed to “Veterinary inputmay be needed… ” to clarify the intent of the sentence.5. Page 43. Original sentence: “The ambient temperature range inwhich thermoregulation occurs without the need to increase metabolicheat production is called the thermoneutral zone (TNZ) andis bounded by the upper (UCT) and lower critical temperatures(LCT).” The phrase “or activate evaporative heat loss mechanisms”and reference to Gordon 2005 were added to provide a more completedefinition of thermoneutral zone.6. Page 45. Original sentence: “In climates where it is difficult to providea sufficient level of environmental relative humidity, animalsshould be closely monitored for negative effects such as excessivelyflaky skin in birds and mammals, ecdysis (molting) difficulties in reptiles,and desiccation stress in semiaquatic amphibians.” Becausethe significance of excessive flaky skin varies among species, “inbirds and mammals” was deleted.7. Page 55. Original sentence: “Thus there is no ideal formula forcalculating an animal’s space needs based only on body size orweight.” The phrase “and readers should take the performanceindices discussed in this section into consideration when utilizingthe species-specific guidelines presented in the following pages”was added to further clarify the intent of this section.8. Pages 57-63. The phrase “the interpretation of this table shouldtake into consideration the performance indices described in thetext beginning on page 55” was added as a footnote to tables asadditional guidance to their interpretation. Additionally, the symbol“≥” was restored (due to mistaken deletion) in Table 3.2 (micein groups; rats in groups; hamsters; guinea pigs) and added toTables 3.5 (group 8) and 3.6 (sheep and goats)9. Page 69. Original sentence: “Cedar shavings are not recommendedbecause they emit aromatic hydrocarbons that induce hepatic microsomalenzymes and cytotoxicity (Torronen et al. 1989; Weichbrodet al. 1986, 1988).” Text mistakenly deleted was restored to theend of the sentence: “and have been reported to increase the incidenceof cancer (Jacobs and Dieter 1978; Vlahakis 1977).”
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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0GUIdE FOR ThE CARE ANd USE OF LAbO
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Page 132 and 133: 4Veterinary CareVeterinary care is
Page 134 and 135: VETERINARy CARE10from these sources
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Page 140 and 141: VETERINARy CARE 113and serology. If
Page 142 and 143: VETERINARy CARE 115RecordkeepingMed
Page 144 and 145: VETERINARy CARE11traffic (AORN 2006
Page 146 and 147: VETERINARy CARE11Specific steriliza
Page 148 and 149: VETERINARy CARE 121(all), anorexia
Page 150 and 151: VETERINARy CARE 123used in combinat
Page 152 and 153: VETERINARy CARE 125Arndt SS, Lohave
Page 154 and 155: VETERINARy CARE12Haines DC, Gorelic
Page 156 and 157: VETERINARy CARE12Morton CM, Reid J,
Page 158: VETERINARy CARE 131Stoskopf MK. 199
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Page 186: Appendices
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Page 226 and 227: appendixBU.S. Government Principles
Page 228 and 229: appendixCStatement of TaskThe use o
Page 230 and 231: appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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