Guide for the Care and Use of Laboratory Animals - Office of ...

156 AddENdUM4. Page 32. Original sentence: “Appropriate veterinary input is neededfor projects involving capture, individual identification, sedation,anesthesia, surgery, recovery, holding, transportation, release, oreuthanasia.” Beginning of sentence changed to “Veterinary inputmay be needed… ” to clarify the intent of the sentence.5. Page 43. Original sentence: “The ambient temperature range inwhich thermoregulation occurs without the need to increase metabolicheat production is called the thermoneutral zone (TNZ) andis bounded by the upper (UCT) and lower critical temperatures(LCT).” The phrase “or activate evaporative heat loss mechanisms”and reference to Gordon 2005 were added to provide a more completedefinition of thermoneutral zone.6. Page 45. Original sentence: “In climates where it is difficult to providea sufficient level of environmental relative humidity, animalsshould be closely monitored for negative effects such as excessivelyflaky skin in birds and mammals, ecdysis (molting) difficulties in reptiles,and desiccation stress in semiaquatic amphibians.” Becausethe significance of excessive flaky skin varies among species, “inbirds and mammals” was deleted.7. Page 55. Original sentence: “Thus there is no ideal formula forcalculating an animal’s space needs based only on body size orweight.” The phrase “and readers should take the performanceindices discussed in this section into consideration when utilizingthe species-specific guidelines presented in the following pages”was added to further clarify the intent of this section.8. Pages 57-63. The phrase “the interpretation of this table shouldtake into consideration the performance indices described in thetext beginning on page 55” was added as a footnote to tables asadditional guidance to their interpretation. Additionally, the symbol“≥” was restored (due to mistaken deletion) in Table 3.2 (micein groups; rats in groups; hamsters; guinea pigs) and added toTables 3.5 (group 8) and 3.6 (sheep and goats)9. Page 69. Original sentence: “Cedar shavings are not recommendedbecause they emit aromatic hydrocarbons that induce hepatic microsomalenzymes and cytotoxicity (Torronen et al. 1989; Weichbrodet al. 1986, 1988).” Text mistakenly deleted was restored to theend of the sentence: “and have been reported to increase the incidenceof cancer (Jacobs and Dieter 1978; Vlahakis 1977).”