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APPENdIX A: AddITIONAL SELECTEd REFERENCES 165Role of ancillary variables in the design, analysis, and interpretation of animal experiments.2002. Gaines Das R. ILAR J 43:214-222.Sample size determination. 2002. Dell RB, Holleran S, Ramakrishnan R. ILAR J43:207-213.Use of factorial designs to optimize animal experiments and reduce animal use. 2002.Shaw R, Festing MFW, Peers I, Furlong L. ILAR J 43:223-232.Primer of Biostatistics, 6th ed. 2005. Glantz SA. New York: McGraw-Hill.Sample size determination (Appendix A). 2003. National Research Council. In: Guidelines forthe Care and Use of Mammals in Neuroscience and Behavioral Research. Washington:National Academies Press. p 175-180.Statistical Methods, 8th ed. 1989. Snedecor GW, Cochran WG. Ames: Iowa State Press.The Design and Analysis of Long-Term Animal Experiments. 1986. Gart JJ, Krewski D, Lee PN,Tarone RE, Wahrendorf J. Lyon: International Agency for Research on Cancer.The Design of Animal Experiments: Reducing the Use of Animals in Research Through BetterExperimental Design. 2002. Festing MFW, Overend P, Gaines Das R, Cortina Borja M,Berdoy M. London: Royal Society of Medicine Press.What is it like to be a rat? Rat sensory perception and its implications for experimental designand rat welfare. 2008. Burn CC. Appl Anim Behav Sci 112:1-32.Research and Testing MethodologyAdjuvants and Antibody Production. 1995. ILAR J 37(3).Advanced Physiological Monitoring in Rodents. 2002. ILAR J 43(3).Mechanical ventilation for imaging the small animal. Hedlund LW, Johnson GA. 2002.ILAR J 43:159-174.Miniaturization: An overview of biotechnologies for monitoring the physiology andpathophysiology of rodent animal models. 2002. Goode TL, Klein HJ. ILAR J43:136-146.Casarett and Doull’s Toxicology: The Basic Science of Poisons, 8th ed. 2007. Klaassen CD.New York: McGraw-Hill.Categorising the Severity of Scientific Procedures on Animals: Summary and Reports fromThree Roundtable Discussions. 2004. Smith JA, Jennings M, eds. West Sussex UK: RSPCA,Research Animals Department. Available at www.boyd-group.demon.co.uk/severity_report.pdf;accessed January 24, 2010.Clinical considerations in rodent bioimaging. 2004. Colby LA, Morenko BJ. Comp Med54:623-630.Effects of Freund’s complete adjuvant on the physiology, histology, and activity of New Zealandwhite rabbits. 2004. Halliday LC, Artwohl JE, Bunte RM, Ramakrishnan V, Bennett BT.Contemp Top Lab Anim Sci 43:8-13.Ethological research techniques and methods. 1998. Novak MA, West M, Bayne KL, Suomi SJ.In: Hart L, ed. Responsible Conduct of Research in Animal Behavior. New York: OxfordUniversity Press. p 51-66.Genetic Engineering and Animal Welfare: Preparing for the 21st Century. 1999. Gonder JC,Prentice ED, Russow L-M, eds. Greenbelt MD: Scientists Center for Animal Welfare.Guidance for Industry and Other Stakeholders: Toxicological Principles for the Safety Assessmentof Food Ingredients, Redbook 2000 (rev 2007). FDA. Available at www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodIngredientsandPackaging/Redbook/default.htm;accessed May 15, 2010.Humane Endpoints for Animals Used in Biomedical Research and Testing. 2000. ILAR J41(2).
166 GUIdE FOR ThE CARE ANd USE OF LAbORATORy ANIMALSHumane endpoints for laboratory animals used in toxicity testing. 2000. Stokes WS. In: Proceedingsof the 3rd World Congress on Alternatives and Animal Use in the Life Sciences,Bologna, Italy, 1999. New York: Elsevier.Humane endpoints in animal experiments for biomedical research: Proceedings of the InternationalConference, 22-25 November 1998, Zeist, the Netherlands.Immunization Procedures and Adjuvant Products. 2005. ILAR J 46(3).Adjuvants and antibody production: Dispelling the myths associated with Freund’s completeand other adjuvants. 2005. Stills JF Jr. ILAR J 46:280-293.Advances in monoclonal antibody technology: Genetic engineering of mice, cells, andimmunoglobulins. 2005. Peterson NC. ILAR J 46:314-319.Applications and optimization of immunization procedures. 2005. Schunk MK, MacallumGE. ILAR J 46:241-257.Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications,and information. 2005. Lipman NS, Jackson LR, Trudel LJ, Weis-Garcia F. ILAR J46:258-268.Using polyclonal and monoclonal antibodies in regulatory testing of biological products.2005. Clough NE, Hauer PJ. ILAR J 46:300-306.Impact of Noninvasive Technology on Animal Research. 2001. ILAR J 42(3).Challenges in small animal noninvasive imaging. 2001. Balaban RS, Hampshire VA. ILARJ 42:248-262.Nuclear magnetic resonance spectroscopy and imaging in animal research. 2001.Chatham JC, Blackband SJ. ILAR J 42:189-208.Use of positron emission tomography in animal research. 2001. Cherry SR, Gambhir SS.ILAR J 42:219-232.Integration of safety pharmacology endpoints into toxicology studies. 2002. Luft J, Bode G.Fundam Clin Pharmacol 16:91-103.Joint Working Group on Refinement: Refinements in telemetry procedures. Seventh report ofthe BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement, Part A. 2003.Morton DB, Hawkins P, Beyan R, Heath K, Kirkwood J, Pearce P, Scott L, Whelan G,Webb A. Lab Anim 37:261-299. Available at www.rspca.org.uk/ImageLocator/LocateAsset?asset=document&assetId=1232712323332&mode=prd; accessed August 10, 2010.Methods and Welfare Considerations in Behavioral Research with Animals. 2002. Report of aNational Institutes of Health Workshop. NIMH. Available at www.nimh.nih.gov/researchfunding/grants/animals.pdf;accessed January 24, 2010.Monoclonal Antibody Production. 1999. National Research Council. Washington: NationalAcademy Press.Physiologic and behavioral assessment of rabbits immunized with Freund’s complete adjuvant.2000. Halliday LC, Artwohl JE, Hanly WC, Bunte RM, Bennett BT. Contemp Top LabAnim Sci 39:8-13.Physiological monitoring of small animals during magnetic resonance imaging. 2005. MirsattariSM, Bihari F, Leung LS, Menon RS, Wang Z, Ives JR, Bartha R. J Neurosci Meth144:207-213.Principles and Methods in Toxicology, 4th ed. 2007. Hayes AW. Philadelphia: Taylor andFrancis.Refinement of neuroscience procedures using nonhuman primates. 2005. Wolfensohn S, PetersA. Anim Technol Welf 4:49-50.Regulatory Testing and Animal Welfare. 2002. ILAR J 43(Suppl).Animal care best practices for regulatory testing. 2002. Fillman-Holliday D, Landi MS.ILAR J 43:S49-S58.Animal use in the safety evaluation of chemicals: Harmonization and emerging needs.2002. Spielmann H. ILAR J 43:S11-S17.
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM1used (C
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3Environment, Housing,and Managemen
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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Page 226 and 227: appendixBU.S. Government Principles
Page 228 and 229: appendixCStatement of TaskThe use o
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Page 232 and 233: APPENdIX d: AbOUT ThE AUThORS 205of
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Page 236 and 237: IndexAAcclimation and adaptation, 1
Page 238 and 239: INdEX 211Behavioral and social mana
Page 240 and 241: INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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