198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

More documents

Recommendations

Info

196 M.R. Caira INTENSITY 283 K 293 K 303 K 305 K 307 K 309 K 311 K 313 K 323 K 2 3 4 5 6 7 8 2 q / DEGREES SOLVATE C SOLVATE A Fig. 13. In situ X-ray diffraction patterns of an antibiotic substance for crystallization range 283–323 K. (Reprinted with permission from [149]) accelerate data-acquisition, enhancement of 13 C magnetisation is achieved by the CP (“cross polarization”) strategy and the combined method is referred to as CPMAS NMR spectroscopy. With it, polymorphic conformational differences, crystal packing differences and the effects of hydrogen bonding may be characterised. Varying the sample temperature allows dynamic studies of solid-solid phase transformations. Incorporation of solvents in pseudopolymorphs introduces significant changes in local environmental magnetic effects through, e.g., hydrogen bonding, and such changes are therefore also open to study by the CPMAS technique. Figure 14 shows 15 N CPMAS spectra for four polymorphic modifications [150] of the imidazole derivative (3), from which it is clear that 15 N chemical shifts are good indices for their identification. 13 C CPMAS has also recently been used to distinguish three polymorphs of complex triacylglycerols [151]. Spectral
Crystalline Polymorphism of Organic Compounds 197 D C B A NO 2 –N= NH 400 350 300 250 200 150 100 50 Fig. 14. 15 N CPMAS spectra for four polymorphs of the imidazole derivative 3. (Reprinted with permission from [150], copyright 1996, Gordon and Breach Publishers) differences were used to characterise conformations and crystal packing differences in the three forms. Examples of applications of CPMAS to the study of polymorphism and pseudopolymorphism of pure drug substances [27] as well as drug-excipient mixtures [152] have been described. In a recent study of the molecular motion in the crystal of the salt (4), the results of 13 C CPMAS NMR and high-resolution powder XRD were combined 3 imidazole derivative 4 salt PPM
Page 1 and 2:
198 Topics in Current Chemistry Edi
Page 3 and 4:
Design of Organic Solids Volume Edi
Page 5 and 6:
Volume Editors Prof. Dr. Edwin Webe
Page 7 and 8:
VIII preface tion at an amazing lev
Page 9 and 10:
Contents of Volume 196 Carbon Rich
Page 11 and 12:
2 J.P. Glusker 5 Interactions of Pl
Page 13 and 14:
4 J.P. Glusker Perturbations to the
Page 15 and 16:
6 J.P. Glusker 2.1 Sources of Cryst
Page 17 and 18:
8 J.P. Glusker other induced, will
Page 19 and 20:
10 J.P. Glusker The forces here hav
Page 21 and 22:
12 J.P. Glusker lographic structure
Page 23 and 24:
14 J.P. Glusker a c Fig. 6 a - c. D
Page 25 and 26:
16 J.P. Glusker hydrogen bond H◊
Page 27 and 28:
18 J.P. Glusker Fig. 9. Citric acid
Page 29 and 30:
20 J.P. Glusker peptide plane and a
Page 31 and 32:
22 J.P. Glusker 4.5 F◊◊◊H Int
Page 33 and 34:
24 J.P. Glusker rine-containing com
Page 35 and 36:
26 J.P. Glusker Fig. 17. The packin
Page 37 and 38:
28 J.P. Glusker bind to a metal ion
Page 39 and 40:
30 J.P. Glusker As for carboxylate
Page 41 and 42:
32 J.P. Glusker Fig. 24. The magnes
Page 43 and 44:
34 J.P. Glusker structures of magne
Page 45 and 46:
36 J.P. Glusker b a Fig. 28 a, b. A
Page 47 and 48:
38 J.P. Glusker Fig. 30. Complexati
Page 49 and 50:
40 J.P. Glusker 7.1 Descriptions of
Page 51 and 52:
42 J.P. Glusker Fig. 34. Glycine cr
Page 53 and 54:
44 J.P. Glusker bonding capabilitie
Page 55 and 56:
46 J.P. Glusker 2. Non-intercalativ
Page 57 and 58:
48 J.P. Glusker d Fig. 37 d. The ch
Page 59 and 60:
50 J.P. Glusker Fig. 39. Hydrogen-b
Page 61 and 62:
52 J.P. Glusker 72, 104], but other
Page 63 and 64:
54 J.P. Glusker 23. Cody V, Murray-
Page 65 and 66:
56 J.P. Glusker: Directional Aspect
Page 67 and 68:
58 A. Nangia · G.R. Desiraju 7 Sup
Page 69 and 70:
60 A. Nangia · G.R. Desiraju elect
Page 71 and 72:
62 A. Nangia · G.R. Desiraju 14 15
Page 73 and 74:
64 A. Nangia · G.R. Desiraju [23]
Page 75 and 76:
66 A. Nangia · G.R. Desiraju struc
Page 77 and 78:
68 A. Nangia · G.R. Desiraju Fig.
Page 79 and 80:
70 A. Nangia · G.R. Desiraju -NH 2
Page 81 and 82:
72 A. Nangia · G.R. Desiraju ingfu
Page 83 and 84:
74 A. Nangia · G.R. Desiraju and r
Page 85 and 86:
76 A. Nangia · G.R. Desiraju bonds
Page 87 and 88:
78 A. Nangia · G.R. Desiraju 2.86-
Page 89 and 90:
80 A. Nangia · G.R. Desiraju from
Page 91 and 92:
82 A. Nangia · G.R. Desiraju ted a
Page 93 and 94:
84 A. Nangia · G.R. Desiraju envir
Page 95 and 96:
86 A. Nangia · G.R. Desiraju PYRAZ
Page 97 and 98:
88 A. Nangia · G.R. Desiraju napht
Page 99 and 100:
90 A. Nangia · G.R. Desiraju b c F
Page 101 and 102:
92 A. Nangia · G.R. Desiraju all a
Page 103 and 104:
94 A. Nangia · G.R. Desiraju 42. J
Page 105 and 106:
Hydrogen-Bonded Ribbons, Tapes and
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
132 Y. Aoyama 4 Catalysis . . . . .
Page 141 and 142:
134 Y. Aoyama 2.2 Symmetry-Controll
Page 143 and 144:
136 Y. Aoyama A trigonal centre is
Page 145 and 146:
138 Y. Aoyama 18 19 Fig. 5. 2D net
Page 147 and 148:
140 Y. Aoyama 24 ded (O-H◊◊◊O
Page 149 and 150:
142 Y. Aoyama 2.4 Interaction-Suppo
Page 151 and 152: 144 Y. Aoyama In the presence of a
Page 153 and 154: 146 Y. Aoyama clusion compounds (se
Page 155 and 156: 148 Y. Aoyama are intriguing guests
Page 157 and 158: 150 Y. Aoyama The tuning or enginee
Page 159 and 160: 152 Y. Aoyama Fig. 16. Binding isot
Page 161 and 162: 154 Y. Aoyama The desorption of the
Page 163 and 164: 156 Y. Aoyama Fig. 17. Suggested me
Page 165 and 166: 158 Y. Aoyama 5 Concluding Remarks
Page 167 and 168: 160 Y. Aoyama 4. Hölderich W, Hess
Page 169 and 170: Crystalline Polymorphism of Organic
Page 201: Crystalline Polymorphism of Organic
Page 215 and 216: Author Index Volumes 151-198 Author
Page 217 and 218: Author Index Volumes 151 - 198 2 1
Page 219 and 220: Author Index Volumes 151 - 198 213
Page 223 and 224: Author Index Volumes 151 - 198 2 ]
Page 227 and 228: Springer and the environment At Spr
show all

198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?