198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

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Directional Aspects of Intermolecular Interactions 47 b c Fig. 37 b, c. b Stereoview of the binding viewed along the chromophore axis; c stereoview of the binding viewed down the helix axis – the daunomycin molecules are depicted with heavy filled bonds
48 J.P. Glusker d Fig. 37 d. The chemical formula of a bisintercalator, WP 631 [97] cin derivative (named WP631, see Fig. 38) is a promising antitumor agent with a very high affinity for DNA; binding constants are 1.6 ¥ 10 7 M –1 for daunomycin and 2.7 ¥ 10 11 M –1 for WP631 [98]. Except for some conformational flexing of the aminosugar, the structures are similar with or without the linker. The major change is in the region of the linker. It appears that intermolecular interactions in which a flat aromatic group is intercalated in DNA have some directionality in that the chromophore in daunomycin and adriamycin complexes generally lies in the same position even though some of the peripheral binding interactions are different. Minor groove binders to DNA are generally A◊ T specific and fit snugly in the narrow minor groove. Such drugs are replacements for well-ordered water molecules found in the absence of drugs. Netropsin and distamycin A, which are pyrrole-amidine oligopeptide antibiotics, bind very tightly to A◊ T regions of
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198 Topics in Current Chemistry Edi
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Design of Organic Solids Volume Edi
Page 5 and 6: Volume Editors Prof. Dr. Edwin Webe
Page 7 and 8: VIII preface tion at an amazing lev
Page 9 and 10: Contents of Volume 196 Carbon Rich
Page 11 and 12: 2 J.P. Glusker 5 Interactions of Pl
Page 13 and 14: 4 J.P. Glusker Perturbations to the
Page 15 and 16: 6 J.P. Glusker 2.1 Sources of Cryst
Page 17 and 18: 8 J.P. Glusker other induced, will
Page 19 and 20: 10 J.P. Glusker The forces here hav
Page 21 and 22: 12 J.P. Glusker lographic structure
Page 23 and 24: 14 J.P. Glusker a c Fig. 6 a - c. D
Page 25 and 26: 16 J.P. Glusker hydrogen bond H◊
Page 27 and 28: 18 J.P. Glusker Fig. 9. Citric acid
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Page 33 and 34: 24 J.P. Glusker rine-containing com
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Page 61 and 62: 52 J.P. Glusker 72, 104], but other
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Page 103 and 104: 94 A. Nangia · G.R. Desiraju 42. J
Page 105 and 106: Hydrogen-Bonded Ribbons, Tapes and
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Hydrogen-Bonded Ribbons, Tapes and
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132 Y. Aoyama 4 Catalysis . . . . .
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134 Y. Aoyama 2.2 Symmetry-Controll
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136 Y. Aoyama A trigonal centre is
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138 Y. Aoyama 18 19 Fig. 5. 2D net
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140 Y. Aoyama 24 ded (O-H◊◊◊O
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142 Y. Aoyama 2.4 Interaction-Suppo
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144 Y. Aoyama In the presence of a
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146 Y. Aoyama clusion compounds (se
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148 Y. Aoyama are intriguing guests
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150 Y. Aoyama The tuning or enginee
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152 Y. Aoyama Fig. 16. Binding isot
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154 Y. Aoyama The desorption of the
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156 Y. Aoyama Fig. 17. Suggested me
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158 Y. Aoyama 5 Concluding Remarks
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160 Y. Aoyama 4. Hölderich W, Hess
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Crystalline Polymorphism of Organic
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Author Index Volumes 151-198 Author
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Author Index Volumes 151 - 198 2 1
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Author Index Volumes 151 - 198 213
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Author Index Volumes 151 - 198 2 ]
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Springer and the environment At Spr
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198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

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