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198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

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204 M.R. Caira<br />

angle which matches that of the substrate ledge site. Successful application of<br />

this pr<strong>in</strong>ciple to the selective nucleation and growth of a thermodynamically<br />

less favoured polymorph of a complex organic salt on succ<strong>in</strong>ic acid s<strong>in</strong>gle<br />

crystals as substrates has recently been reported [169].<br />

The approaches outl<strong>in</strong>ed above cont<strong>in</strong>ue to provi<strong>de</strong> new <strong>in</strong>sights <strong>in</strong>to the<br />

fundamental process of crystallization of organic molecules and studies of the<br />

type <strong>de</strong>scribed promise to contribute very significantly <strong>in</strong> the future to a <strong>de</strong>tailed<br />

un<strong>de</strong>rstand<strong>in</strong>g of the molecular orig<strong>in</strong>s of crystal polymorphism and to its<br />

effective control. The author believes that the phenomenon of polymorphism<br />

will, notwithstand<strong>in</strong>g such progress, reta<strong>in</strong> its aura as a remarkable manifestation<br />

of Nature’s diversity.<br />

Acknowledgements. My thanks are due to my colleague Prof L R Nassimbeni for constructive<br />

comments and to Fiona Jones for assistance with library resources. Research support from the<br />

University of Cape Town and the FRD (Pretoria) is gratefully acknowledged.<br />

5<br />

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