198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

More documents

Recommendations

Info

Directional Aspects of Intermolecular Interactions 29 5.2 Surroundings of Imidazole and Histidine Groups Histidine residues are common in the active sites of enzymes and for binding metal ions, especially divalent zinc and copper ions [60]. Imidazole groups in histidyl side chains bind in proteins to metal ions, but the metal cation nearly always lies in or very near the plane of the imidazole group along the lone-pair direction of the nitrogen atom. This has been verified by studies of crystal structures in the CSD [61]. One imidazole group, since it has two nitrogen atoms, can bind one or two metal ions, Zn 2+ ,Fe 2+ , and Cu 2+ being common binders. In proteins [62], the metal ion shows a preference for binding to the nitrogen atom furthest from the C a of the histidine, as shown in Fig. 20; the identity of the metal ion does not appear to affect the overall geometry. The histidine group may be precisely oriented by additional hydrogen bonding, as shown in Fig. 21. Fig. 20. A metal ion binding to histidine [61]. There are two positions available for metal ion binding. Alternatively the positions can be used for the formation of hydrogen bonds Fig. 21. Constraints of hydrogen bonding on the orientation of a histidine side chain in D-xylose isomerase [81]. The backbone of the protein is indicated by filled bonds. Note that the aspartate side chain is constrained in position by the backbone -NH- group of the histidine, and that the orientation of the histidine ring system is constrained by this constrained aspartate group
30 J.P. Glusker As for carboxylate groups it is found that transition-metal ions lie closer to the plane of the imidazole than do hydrogen bonding groups [63]. Thus metal ion binding is more precisely directional. 5.3 Surroundings of Arginine Side Chains in Proteins Arginine side chains in proteins provide an excellent means of aligning carboxylate and phosphate groups so that an O-C-O or O-P-O group lies in the plane of the arginine. This multidentate protein side chain is used with success in protein-nucleic interactions, as shown in Fig. 22 [64]. a b c Fig. 22 a – c. Arginine interactions [64]: a with indicated hydrogen bond directions; b the binding of a carboxylate group; c the binding of a phosphate group
Page 1 and 2: 198 Topics in Current Chemistry Edi
Page 3 and 4: Design of Organic Solids Volume Edi
Page 5 and 6: Volume Editors Prof. Dr. Edwin Webe
Page 7 and 8: VIII preface tion at an amazing lev
Page 9 and 10: Contents of Volume 196 Carbon Rich
Page 11 and 12: 2 J.P. Glusker 5 Interactions of Pl
Page 13 and 14: 4 J.P. Glusker Perturbations to the
Page 15 and 16: 6 J.P. Glusker 2.1 Sources of Cryst
Page 17 and 18: 8 J.P. Glusker other induced, will
Page 19 and 20: 10 J.P. Glusker The forces here hav
Page 21 and 22: 12 J.P. Glusker lographic structure
Page 23 and 24: 14 J.P. Glusker a c Fig. 6 a - c. D
Page 25 and 26: 16 J.P. Glusker hydrogen bond H◊
Page 27 and 28: 18 J.P. Glusker Fig. 9. Citric acid
Page 29 and 30: 20 J.P. Glusker peptide plane and a
Page 31 and 32: 22 J.P. Glusker 4.5 F◊◊◊H Int
Page 33 and 34: 24 J.P. Glusker rine-containing com
Page 35 and 36: 26 J.P. Glusker Fig. 17. The packin
Page 37: 28 J.P. Glusker bind to a metal ion
Page 41 and 42: 32 J.P. Glusker Fig. 24. The magnes
Page 43 and 44: 34 J.P. Glusker structures of magne
Page 45 and 46: 36 J.P. Glusker b a Fig. 28 a, b. A
Page 47 and 48: 38 J.P. Glusker Fig. 30. Complexati
Page 49 and 50: 40 J.P. Glusker 7.1 Descriptions of
Page 51 and 52: 42 J.P. Glusker Fig. 34. Glycine cr
Page 53 and 54: 44 J.P. Glusker bonding capabilitie
Page 55 and 56: 46 J.P. Glusker 2. Non-intercalativ
Page 57 and 58: 48 J.P. Glusker d Fig. 37 d. The ch
Page 59 and 60: 50 J.P. Glusker Fig. 39. Hydrogen-b
Page 61 and 62: 52 J.P. Glusker 72, 104], but other
Page 63 and 64: 54 J.P. Glusker 23. Cody V, Murray-
Page 65 and 66: 56 J.P. Glusker: Directional Aspect
Page 67 and 68: 58 A. Nangia · G.R. Desiraju 7 Sup
Page 69 and 70: 60 A. Nangia · G.R. Desiraju elect
Page 71 and 72: 62 A. Nangia · G.R. Desiraju 14 15
Page 73 and 74: 64 A. Nangia · G.R. Desiraju [23]
Page 75 and 76: 66 A. Nangia · G.R. Desiraju struc
Page 77 and 78: 68 A. Nangia · G.R. Desiraju Fig.
Page 79 and 80: 70 A. Nangia · G.R. Desiraju -NH 2
Page 81 and 82: 72 A. Nangia · G.R. Desiraju ingfu
Page 83 and 84: 74 A. Nangia · G.R. Desiraju and r
Page 85 and 86: 76 A. Nangia · G.R. Desiraju bonds
Page 87 and 88: 78 A. Nangia · G.R. Desiraju 2.86-
Page 89 and 90:
80 A. Nangia · G.R. Desiraju from
Page 91 and 92:
82 A. Nangia · G.R. Desiraju ted a
Page 93 and 94:
84 A. Nangia · G.R. Desiraju envir
Page 95 and 96:
86 A. Nangia · G.R. Desiraju PYRAZ
Page 97 and 98:
88 A. Nangia · G.R. Desiraju napht
Page 99 and 100:
90 A. Nangia · G.R. Desiraju b c F
Page 101 and 102:
92 A. Nangia · G.R. Desiraju all a
Page 103 and 104:
94 A. Nangia · G.R. Desiraju 42. J
Page 105 and 106:
Hydrogen-Bonded Ribbons, Tapes and
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
132 Y. Aoyama 4 Catalysis . . . . .
Page 141 and 142:
134 Y. Aoyama 2.2 Symmetry-Controll
Page 143 and 144:
136 Y. Aoyama A trigonal centre is
Page 145 and 146:
138 Y. Aoyama 18 19 Fig. 5. 2D net
Page 147 and 148:
140 Y. Aoyama 24 ded (O-H◊◊◊O
Page 149 and 150:
142 Y. Aoyama 2.4 Interaction-Suppo
Page 151 and 152:
144 Y. Aoyama In the presence of a
Page 153 and 154:
146 Y. Aoyama clusion compounds (se
Page 155 and 156:
148 Y. Aoyama are intriguing guests
Page 157 and 158:
150 Y. Aoyama The tuning or enginee
Page 159 and 160:
152 Y. Aoyama Fig. 16. Binding isot
Page 161 and 162:
154 Y. Aoyama The desorption of the
Page 163 and 164:
156 Y. Aoyama Fig. 17. Suggested me
Page 165 and 166:
158 Y. Aoyama 5 Concluding Remarks
Page 167 and 168:
160 Y. Aoyama 4. Hölderich W, Hess
Page 169 and 170:
Crystalline Polymorphism of Organic
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Author Index Volumes 151-198 Author
Page 217 and 218:
Author Index Volumes 151 - 198 2 1
Page 219 and 220:
Author Index Volumes 151 - 198 213
Page 221 and 222:
Page 223 and 224:
Author Index Volumes 151 - 198 2 ]
Page 225 and 226:
Page 227 and 228:
Springer and the environment At Spr
show all

198 Topics in Current Chemistry Editorial Board: A. de Meijere KN ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?