ovdje - Hrvatsko filozofsko društvo

all the animals (mouse, rat, rabbit, dog, goat, horse, pig) the rats were 49%
of tested animals. Determination of pharmacodinamic and pharmacokinetic
parameters (T max , C max , t 1/2 ) was conducted on animals and humans by using
scientifically recognized methods. Clinical confirmations of preclinical
results justify using animals in pain research, especially rats. Research must
be in accordance with the recommendations of the ethics committee, and experimental
model of pain in good correlation with clinical pain conditions.
BIOETIČKI PRINCIPI U PRETKLINIČKOM ISPITIVANJU
ANALGETIKA
Korištenje in vivo modela u pretkliničkom ispitivanju lijekova i dalje je
kontroverzno pitanje u bioetici (antropocentrična i biocentrična etika). Životinjama
treba osigurati osnovno pravo na život primjeren njihovoj vrsti. Cilj
istraživanja je bio ispitati opravdanost korištenja životinja u pretkliničkom
istraživanju analgetika (npr. nimesulid). Pretraživana je baza podataka Medline.
Od svih životinja (miš, štakor, kunić, pas, koza, konj, svinja) štakori
su činili 49% eksperimentalnih životinja.Određivanje farmakodinamskih i
farmakokinetičkih parametara (T max , C max , t 1/2 ) provedeno je na životinjama i
ljudima znanstveno priznatim metodama. Kliničke potvrde rezultata pretkliničkih
istraživanja bola opravdavaju korištenje životinja, posebno štakora.
Istraživanje mora biti u skladu s preporukama etičkih komiteta, a eksperimentalni
modeli bola u dobroj korelaciji s kliničkim bolnim stanjima.
VERONIKA SZÁNTÓ
Institute of Philosophy, Loránd Eötvös University, Budapest, Hungary /
Institut za filozofiju, Sveučilište Loránda Eötvösa u Budimpešti, Mađarska
THE EMERGENCE OF LIFE:
EARLY MODERN AND CONTEMPORARY THEORIES
OF DEVELOPMENTAL BIOLOGY AND
THEIR ETHICAL SIGNIFICANCE
Throughout history it has been widely discussed whether the development
of embryos was driven by an external agent or by an intrinsic principle.
In this paper I will focus only on those aspects which are related to
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