health and safety plan solid waste management unit assessment

JP-4 (JET FUEL 4) 64-22
64.3 HUMAN HEALTH CONSIDERATIONS
64.3.1 Animal Studies
64.3.1.1 Carcinogenicity
The carcinogenicity of petroleum-derived and shale-derived JP-4
was evaluated in Fischer 344 rats and C57BL/6 mice. The animals were
exposed to vapor concentrations of 5000 or 1000 mg/m3 in whole-body
inhalation chambers. Exposure was for 6 hours daily, 5 days per week
for 1 year. The animals were held for an additional year. The results
of histopathologic evaluation of the tissues are in progress (1936).
No other studies dealing with the carcinogenicity of JP-4 were
located.
64.3.1.2 Mutagenicity
The mutagenicity of JP-4 H-Farm B-42 was evaluated in a number of
in vitrQ and fn vivo assays. Other than an increase in unscheduled DNA
synthesis, test results were negative.
In the Ames test, negative results were obtained in Salmonella
twbriuis strains TA98, 100, 1535, 1537 and 1538 both with and
vithout microsomal activation. Test concentrations ranged from 0.001
to 5.1 rL per plate. Concentrations above 1 pL per plate were toxic to
most of the bacterial strains. Negative results were also seen in
B serevisb strain D4 and in the TR mouse lymphoma cell
assay (1813).
JP-4 H-Farm B-42 produced a dose-related increase in unscheduled
DNA synthesis in WI-38 cells both with and without activation, although
the results from tests with activation were of greater magnitude than
those without (1813).
In the dominant lethal assay, negative results were obtained in
mice given doses of 0.01, 0.03 or 0.09 ml/kg/day for 5 days (1813). In
rats, results were negative overall but significant preimplantation
loss was observed after the fourth mating. Rats received ip doses of
0.09, 0.3 or 0.9 ~&/kg/day for 5 days (1813).
64,3.1.3 Teratogenicity, Embryotoxicity and Reproductive Effects
No studies were found in this area for JP-4.
64.3.1.4 Other Toxicologic Effects
64.3.1.4.1 Short-term Toxicity
No information was found regarding the acute toxic effects of JP-4
in animals. Due to the nature of its components, CNS effects would be
expected. vapors would be irritating to the eyes and mucous membranes
and the liquid would cause irritation and defatting of the,skin (200).
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