health and safety plan solid waste management unit assessment
health and safety plan solid waste management unit assessment
health and safety plan solid waste management unit assessment
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HYDSWJLIC FLUID 68-26<br />
TABLE,68-4<br />
ACUTE TOXICITY<br />
OF SELECTED COMPONENTS OF HYDRAULIC FLUID<br />
Compound<br />
Oral<br />
(ms/ka)<br />
Dormal<br />
trs;/kc)<br />
Inhalation<br />
(ppm)<br />
2-•th~lhoryl~ob~cato<br />
p8ata*rythtitol<br />
pol7prop7lono<br />
g17col<br />
poltoth7lano clyaol<br />
trfphonylpho~pbato<br />
trierorylphotphato<br />
tri-ortbo-croaylphoaphate<br />
trt(2-•thylbow1)<br />
pbo8phato<br />
triothylphoophato<br />
tM.raotb~l silicato<br />
tatr8(2-•thylbutyl)<br />
ailicata<br />
trifluorotrfcblorootha~o<br />
LOsO [ratI: 1280<br />
LOS0 bOU8.J: 2s.500<br />
LOS0 tr8tl: 419<br />
LOI0 [rat]: 33.7~0<br />
LOLo (rat): 3000<br />
LDLo [rat]: 4680<br />
LOso [ratl: 3000<br />
LDLo [humal: 1000<br />
LDsO [rrtl: 37.000<br />
LOLo fratl: 1600<br />
LOLo [r4tl: 1000<br />
LDsO (rat]: 20.000<br />
LOSO [rat]: 43,000<br />
LDLo [rabbit): 20,000<br />
-<br />
LCLO (rat.1 :<br />
1000*4 hr<br />
XL0<br />
-<br />
[rat]:<br />
87000*a hr<br />
Rofermme: 47<br />
No carcinogenic effects were observed in rats orally administered<br />
Ucon@ fluids in the diet or in mice dermally exposed to these compounds<br />
(13).<br />
Polyethylene glycol applied to the open wounds of rabbits resulted<br />
in metabolic acidosis <strong>and</strong> changes in blood chemistry consistent with<br />
nephrotoxicity (2225). Effects were attributed to the metabolism of<br />
polyethylene glycol to toxic compounds (such as hydroxyglycolic <strong>and</strong><br />
diglycolic acid homologues) which are efficient chelators of calcium.<br />
The mechanism of damage was similar to that associated with ethylene<br />
glycol-mediated renal failure. See discussion of the toxic effects of<br />
ethylene glycol in Chapter 43 of the Installation Restoration Program<br />
Toxicology Guide, Volume 2.<br />
No adverse changes in clinical, biochemical or hematological<br />
parameters developed in rats fed 2 ml/kg/day polyethylene glycol 400<br />
(duration not specified) (2224). Examination of monkeys administered<br />
the same treatment revealed a deposition of oxalate crystals in the<br />
cortical tubules of the kidney (2224).<br />
6/87
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