health and safety plan solid waste management unit assessment
health and safety plan solid waste management unit assessment
health and safety plan solid waste management unit assessment
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FUEL OILS<br />
seen in the heart, lung, liver, kidney <strong>and</strong> brain. A one-hour vapor<br />
exposure to 26,752 ppm caused rapid narcosis <strong>and</strong> tremor <strong>and</strong> was lethal<br />
to all exposed rabbits. In mice, concentrations causing narcosis vary<br />
from 14,600 to 122,000 ppm.<br />
Cyclohexane is nominally absorbed through the skin although<br />
massive applications (> 180.2 g/kg) to rabbit skin resulted in<br />
microscopic changes in the liver <strong>and</strong> kidneys <strong>and</strong> caused the death of<br />
all animals.<br />
The danger of chronic poisoning is relatively slight because this<br />
compound is almost completely eliminated from the body. No toxic<br />
changes were seen in rabbits exposed to vapor levels of 434 ppm, 6<br />
hours daily for 50 exposures, but some microscopic changes were scan in<br />
the liver <strong>and</strong> kidneys when the exposure was to 786 ppm for the same<br />
period.<br />
In man, no systemic poisonings by cyclohexane have been reported.<br />
A vapor level of 300 ppm is somewhat irritating to the eyes <strong>and</strong> mucous<br />
membranes. It has been reported that cyclohexane may potentiate the<br />
toxic effects of TOCP but no additional details of this interaction are<br />
available (12,17,46,54,1937).<br />
The primary effects of benzene inhalation <strong>and</strong> ingestion are on the<br />
central nemous system (54). Benzene is carcinogenic in both animals<br />
<strong>and</strong> man. Several reports have established a relationship between<br />
benzene exposure <strong>and</strong> leukemia. For more information, refer to Chapter<br />
18 of the Installation Restoration Program Toxicology Guide, Volume 1.<br />
Toluene<br />
Toluene is a CNS depressant with a low toxicity. For more<br />
information, refer to Chapter 19 of the Installation Restoration<br />
Program Toxicology Guide, Volume 1.<br />
Acute exposure to high concentrations of xylene vapors may cause<br />
CNS depression. Both the liquid <strong>and</strong> the vapor are irritating to the<br />
eyes, mucous membranes <strong>and</strong> skin (46). The National Toxicology Progrsm<br />
recently reported that there was no evidence of carcinogenicity of<br />
mixed xylenes in either mice or rats given daily doses ranging from 250.<br />
to 1000 mg/kg by gavage for 2 years (1939).<br />
For more information, refer to Chapter 21 of the Installation<br />
Restoration Program Toxicology Guide, Volume 1.<br />
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