health and safety plan solid waste management unit assessment

JP-4 (JET FUEL 4) 64-31
mg/kg and 1630 mg/kg have been reported for l-methylnaphthalene and
2-methylnaphthalene, respectively, in the rat (47).
JP-4 Additives
Additives used in JP-4 are listed in Table 64-3. Little
toxicological data were found regarding these compounds. The
information which was available is outlined below:
6-t-butyl-2,4-dimethylphenol
An oral LB,, of 530 mg/kg in the rat was reported (47).
N,N'-di-sac-butyl-p-phenylenediamine
A percutaneous I&, of 5000 mg/kg was reported in guinea
pigs. The lowest lethal oral dose reported in rats is 200
Wk. The LDLo in rats is 600 mg/m3 for 6 hours (1937).
N,N-dimethylformsmide
An oral LB,, of 2800 mg/kg in the rat and 3750 q/kg in the
mouse have been reported. In humans, N,N-dimethylformamide
is irritating to the eyes, skin and mucous membranes. Case
reports have indicated that the liver is the main target
organ following acute and chronic exposure to dimethylformamide.
One of the earliest manifestations of excessive
exposure is ethanol intolerance followed at higher exposure
levels by symptoms of nausea, vomiting and abdominal pain
(1937,2316).
64.3.4 Levels of Concern
No criteria or standards specific for JP-4 were located. EPA
(2012) does list a criterion for .oil and grease which requires domestic
water supplies to be virtually free from oil and grease, particularly
with regard to taste and odor.
OSHA (298) has set a standard of 500 ppm for petroleum distillates
(naphtha). The ACGIH (3) recommends a threshold limit value of 300 ppm
for gasoline, with a short-term exposure limit of 500 ppm.
64.3.5 Hazard Assessment
Toxicological data located for JP-4 are limited. No data are
currently available regarding the carcinogenicity of JP-4 but a study
is in progress (1936). Shale- and petroleum-derived JP-4 have been
tested in F344 rats and C57BL/6 mice at vapor concentrations of 5000 or
10,000 mg/ms. Histopathology is now in progress.
Mutagenicity tests in bacterial and mammalian test systems are
negative as are dominant-lethal tests for both rats and mice (1813).
No data on reproductive.toxicity were located.
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