health and safety plan solid waste management unit assessment

FUEL OILS 66-20
66.3.1.4 Other Toxicologic Effects
66.3.1.4.1 Short-term Toxicity
tests:
The following fuel oils were evaluated for acute toxicity in 6
Diesel Fuel (marketplace sample)
Number 2 fuel oil
low-catalytic cracked (10%)
medium-catalytic cracked (30,%)
high-catalytic cracked (50%)
Number 6 fuel oil
API gravity 11.7/2.7% Sulfur content
API gravity
API gravity
17.1/0.8%
23.1/0.2%
Sulfur
Sulfur
content
content
API gravity 5.2/1.2% Sulfur content
The 6 tests which were conducted were:
m
Primary eye and dermal irritation in rabbits
- Acute dermal and subacute dermal toxicity in rabbits
- Dermal sensitization in guinea pigs
B Acute oral toxicity in rats
Results of these tests are discussed below.
The acute oral toxicity was evaluated in Sprague-Dawley rats. The
number 2 oils caused 70 to 100% mortality with doses of 16.5 to 21
.si% * LD,, values ranged from 12.0 to 17.5 g/kg. Toxic signs included
alopecia, dermal irritation and open sores around the genital area.
The number 6 fuel oil with an API specific gravity of 5.2 and 1.2%
sulfur content was the most toxic material tested. The LD,, was 5.1
i3/kg - A dose of 25 g/kg caused 100% mortality. None of the other
number 6 fuel oils caused mortality at 22-24 g/kg. A significant
degree of gastrointestinal distress was observed at doses greater than
15-20 g/kg until the material cleared the gastrointestinal tract. This
was thought to be due to volume overload. Mortality generally occurred
2-3 days after dosing. Necropsy revealed evidence of hemorrhagic
gastroenteritis and pneumonia with abscess formation (1929).
A marketplace sample of diesel fuel had an LD,, of 7.5 g/kg and
caused 90% mortality at a dose of 16.6 g/kg. Toxic signs were the same
as those seen with the number 2 oils (1924).
Male CD-1 mice subjected to nose only exposure of 0.065, 0.135 or
0.204 q g/L uncombusted diesel fuel vapor for 8 hours per day on 5
consecutive days developed vasodilation, ataxia, poor grooming habits,
and in some cases, tremors. All signs varied with the dose and
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