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health and safety plan solid waste management unit assessment

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HYDRAULIC FLUID 68-29<br />

TABLE 68-5<br />

ACUTE TOXICITY<br />

OF SELECTED ADDITIVES OF HYDRAULIC FLUID<br />

Compound<br />

Darmal (m6/ka) Inhalation (ppm)<br />

2.6-dl-tert-butylp-w0801<br />

phenothiatina<br />

pyridino<br />

Cpill0lin.<br />

hydroquinone<br />

phmyl-alphanaphthylamino<br />

triettmaolamina<br />

2-naphthol<br />

sinc.dithiophosphato<br />

tricrasyl phosphate<br />

trl-ortho-cra*yl<br />

phoaphato<br />

diisobuttlkotona<br />

LDsg [rat): 800<br />

LOsO [rat): 5000<br />

LDLo [child]: 425<br />

LDsO [rat]: 891<br />

LDag [rat]: 331<br />

ID&,, [rat]: 320<br />

LDLo [hurm~l: 29<br />

LOS,, [rat]: 1625<br />

LDsO (rat]: 8600<br />

IDso [rat]: 2420<br />

LDLo [rabbit]: 2130<br />

LDLo [rat]: 4680<br />

LDIO [ratl: 3000<br />

LDLo [human]: 1000<br />

LOso [rat]: 5730<br />

LDLo [rabbit]:<br />

1121<br />

LDso [rabbit] :<br />

3bO<br />

- .<br />

LDsO [rabbit1 :<br />

20.000<br />

LCsO [rat1 :<br />

COOO*S hr<br />

LCLo fratl:<br />

2000.4 hr<br />

LCLo [human]:<br />

50<br />

RaLerance: 47<br />

A reported teratogenic effect of anophthalmia in rats has never<br />

been duplicated (17).<br />

Various morphological <strong>and</strong> biochemical changes have been observed<br />

in experimental animals fed extremely high doses of BHT. Adverse<br />

effects included a dose-dependent reduction in growth rate <strong>and</strong> alveolar<br />

epithelial damage in mice which progressed to fibrosis when pure oxygen,<br />

followed the BHT exposure. Dose-dependent fatalities occurred from<br />

massive hemorrhages into the pleural <strong>and</strong> peritoneal cavities while<br />

survivors suffered hemorrhages of the epididymis, testis, nasal cavity<br />

<strong>and</strong> pancreas. Liver changes in rats, mice <strong>and</strong> monkeys included<br />

enlargement, induction of mfcrosomal enzymes <strong>and</strong> an increased synthesis<br />

of hepatic smooth endoplasmic reticulum (17).<br />

6/87

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