health and safety plan solid waste management unit assessment

AUTOMOTIVE GASOLINE 65-32
spontaneous motor activity and reduced performance coknected with
disturbances of the motor coordination system; however the severity of
these effects does not indicate serious toxic damage to the CNS. The
study concluded that MTBE "does not even minimally increase the
neurologic effects with respect to gasoline itself." The level of
exposure or the species which were tested were not reported (2293).
t-Butvl
alcohol
At high concentrations, t-butyl alcohol causes narcosis in animals
and it is expected to. cause the same effect in humans. Other than
slight skin irritation, no effects have been reported from industrial
exposure. The oral LB,, in the rat is 3500 q/kg (46).
Ethanol is irritating to the eyes and mucous membranes. It is
also a CNS depressant. The acute toxicity of ethanol is low for both
animals and man. Overexposure causes ataxia, incoordination and
drowsiness (2,46). An oral LD,, of 14 g/kg was reported for the rat
(47).
Methanol causes optic neuropathy and metabolic acidosis.
Poisoning has occurred primarily from ingestion of adulterated
alcoholic beverages. After ingestion there is a latency period of 18
to 48 hours after which exposed individuals develop symptoms of nausea,
abdominal pain, headache and shortness of breath. Visual symptoms
range from blurred or double vision to changes in color perception,
constricted visual fields and complete blindness. Other symptoms of
intoxication include dizziness, behavioral disturbances, neuritis and
acidosis. The degree of acidosis has been found to parallel the
severity of the poisoning. Evidence suggests that exposure to vapor
Concentrations of 200-375 ppm causes recurrent headaches and visual
disturbances are seen at vapor levels of 1200-8300 ppm (2,461. An oral
%O of 13 g/kg was reported in the rat (47).
TOCP affects the spinal cord and peripheral nervous system.
Symptoms of acute exposure, including nausea, vomiting, diarrhea and
abdominal pain, are followed by a latent period of 3 to 30 days. At
this time, there is muscle soreness, numbness of fingers,. calf muscles
and toes which progresses to foot and wrist drop. These effects are
manifested after ingestion, inhalation or dermal absorption (54). An
oral LD,, of 1160 mg/lcg has been reported in the rat (47). More
information on TOCP can be found in Chapter 49 of the Installation
Restoration Program Toxicology Guide, Volume 2.
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