health and safety plan solid waste management unit assessment

JP-4 (JET FUEL 4) 64-30
Toluene is a CNS depressant with a low toxicity. For more
information, refer to Chapter 19 of the Installation Restoration
Program Toxicology Guide, Volume 1.
Xvlenes
Acute exposure to high concentrations.of xylene vapors may cause
CNS depression. Both the liquid and the vapor are irritating to the
eyes, mucous membranes and skin (46). The National Toxicology Program
recently reported that there was no evidence of carcinogenicity of
mixed xylenes in either mice or rats given daily doses ranging from 250
to 1000 mg/kg by gavage for 2 years (1939).
For more information, refer to Chapter 21 of the Installation
Restoration Program Toxicology Guide, Volume 1.
Ethvl
Benzene
Ethyl benzene is primarily an irritant to the skin, eyes and upper
respiratory tract. Systemic absorption causes CNS depression (46).
For more information, refer to Chapter 20 of the Installation
Restoration Program Toxicology Guide, Volume 1.
aimethy&enzeneg
The trimethylbenzenes occur in 3 isomeric forms. The 1,3,S-isomer
(mesitylene) and the 1,2,4-isomer (pseudocumene) are toxicologically
similar. High vapor concentrations (5000-9000 ppm) cause CNS
depression in animals. Loss of reflexes was seen in mice exposed to
8130-9140 ppm of the 1,2,4-isomer or 8130 ppm of the 1,3,5-isomer.
Rats exposed to 1700 ppm of an isomeric mixture for lo-21 days had no
adverse effects or fatalities.
The fatal intraperitoneal dose of the 1,2,4-isomer for the guinea
pig is 1.788 g/kg, while the fatal dose of the 1,3,5-isomer by the same
route is 1.5-2 g/kg for the rat. For the 1,2,3-isomer, an oral LDLo of
5000 mg/kg has been reported in the rat. Trimethylbenzene liquid is a
primary skin irritant. Deposition into the lungs causes pneumonitis at
the site of contact.
The only report of human exposure described symptoms of
nervousness, tension, anxiety, asthmatic bronchitis, hypochromic anemia
and changes in the coagulability of the blood. Vapor concentrations
ranged from lo-60 ppm. Exposure was to a mixture containing 30% of the
1,3,5-isomer and 50% of the 1,2,4-isomer (2,12).
The only adverse effects of methylnaphthalene reported in man are
skin irritation and photosensitization (17). Oral LD,, values of 1840
6/87