health and safety plan solid waste management unit assessment

AUTOMOTIVE GASOLINE 65-28
10 months in mild to moderate cases, but may take up to 3 years in
serious cases. The threshold level at which neuropathy occurs has not
been firmly established but symptoms have been observed in people
exposed to concentrations ranging from 10 to 200 ppm for 9-12 months.
In animals, signs of narcosis are seen after mice are exposed to
vapor levels of 16,000 ppm for 5 minutes. Death generally occurred at
concentrations between 43,800 and 52,000 ppm after 9-119 minutes. The
oral Lb,, is cited as 24 mL/kg for 14-day-old rats and 49 mL/kg for
young adult rats.
Long-term inhalation experiments. in rats suggest that the first
signs of neurotoxicity appear after they are exposed to levels of 200
ppm for 24 weeks. This higher threshold to induce neurotoxicity in
animals may be due to differences in metabolism. Specifically,
2-hexanol is the chief metabolite in animals, while 2,5-hexanediona
which is neurotoxic, predominates in man. Chronic topical application
of a solvent containing 35.2% n-hexane caused axonal swelling and
myelin degeneration in chicks. No clinical signs were seen. Dosage
was 1 g/kg/day for 64 days. In rabbits, topical application of 0.5
ml/day for up to 10 days caused redness, irritation and scab formation.
N-hexane is neither carcinogenic or teratogenic. One & vivo study in
rats that inhaled 150 ppm for 5 days found an increased number of
chromosome. aberrations in the bone marrow cells. No studies on
mutagenicity, reproductive toxicity or carcinogenicity in man were
found (;2,1930,1935).
Isopentane is a CNS depressant. Effects may include exhilaration,
dizziness, headache, loss of appetite, nausea, confusion, inability to
do fine work, a persistent taste of gasoline and in extreme cases, loss
of consciousness. Inhalation of up to 500 ppm appears to have no
effect on humans. "Very high" vapor concentrations are irritating to
the skin and eyes. Repeated or prolonged skin contact will dry and
defat skin resulting in irritation and dermatitis. The LC,, in the
mouse is estimated to be 1000 mg/L (12).
(isohexane,
3-methylpentane)
No physiological data are available but isohexanes are expected to
be mucous membrane irritants and to have a low oral toxicity.
Isohexanes are predicted to have narcotic properties and are documented
to be cardiac sensitizers but are not expected to have neurotoxic
properties (12).
Cyclohexane is a CNS depressant of low toxicity. Symptoms of
acute exposure are excitement, loss of equilibrium, stupor and coma.
Rarely, death results due to respiratory failure. The anesthesia which
is induced is weak and of brief duration but more potent than that
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