NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
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in commercially available seaweeds is now in press, <strong>and</strong> the second paper on bioavailability of seaweed iodine has been<br />
submitted for publication.<br />
DTIC<br />
Aquatic Plants; Cancer; Cells (Biology); Diets; Mammary Gl<strong>and</strong>s; Seaweeds<br />
20040111578 Texas Univ., Austin, TX<br />
Alendronate <strong>and</strong> Hormone Replacement Therapy in the Prevention of Osteoporotic Fracture: A Pharmacoeconomic<br />
Analysis Employing a Net-Benefit Regression Method of Cost- Effectiveness<br />
Tiller, Kevin W.; Aug. 2004; 323 pp.; In English<br />
Report No.(s): AD-A425640; CI04-576; No Copyright; Avail: CASI; A14, Hardcopy<br />
Osteoporosis is a common chronic condition which poses a substantial clinical, economic, <strong>and</strong> health-related<br />
quality-of-life (HRQOL) burden to the individual, the U.S. health care system, <strong>and</strong> society in general. The overall objective<br />
of this study was to evaluate the economic, clinical <strong>and</strong> humanistic outcomes of current osteoporosis interventions employed<br />
in the prevention of osteoporotic fractures in the Department of Defense (DoD) population. The overall objective encompassed<br />
four primary objectives: to assess the epidemiology of osteoporotic fracture in women \g age 50; to determine the effectiveness<br />
of current osteoporosis interventions; to identify significant risk factors <strong>and</strong> other covariates in the prediction of osteoporotic<br />
fracture; <strong>and</strong> to determine the cost- effectiveness of current osteoporosis interventions. A three-year sample-based<br />
retrospective cohort study was conducted using DoD health care <strong>and</strong> prescription claims from fiscal years 2000 to 2003. Using<br />
an intent-to- treat study design, a total of 49,851 women \g age 50 were followed for osteoporotic fracture. The effectiveness<br />
of the interventions was determined by performing a series of both logistic <strong>and</strong> direct Cox proportional hazard regressions.<br />
The net-benefit regression method of cost-effectiveness was employed to determine the cost-effectiveness of the treatment<br />
interventions <strong>and</strong> to determine the importance of covariates on the marginal cost-effectiveness of an intervention, while<br />
statistically controlling for the presence of risk factors <strong>and</strong> other covariates. The epidemiologic study results showed that the<br />
three-year cumulative incidence of an osteoporotic fracture was 2.5 % for the cohort (0.4% in patients without a diagnosis of<br />
osteoporosis; 6.1% in patients with a diagnosis of osteoporosis).<br />
DTIC<br />
Cost Effectiveness; Diagnosis; Hormones; Medical Services; Osteoporosis; Prevention; Replacing; Therapy<br />
20040111580 Uniformed Services Univ. of the Health Sciences, Bethesda, MD<br />
Correlation Between Measured Ambient Airborne Particulate Matter (PM10) Concentrations <strong>and</strong> Ophthalmologic<br />
Disease Non-Battle Injury (DNBI) Rates in Active Duty Personnel Deployed to a US Military Base in Central<br />
Comm<strong>and</strong> (CENTCOM) Between October 1999 <strong>and</strong> September 2001<br />
Selent, Monica U.; Jun. 2004; 26 pp.; In English<br />
Report No.(s): AD-A425642; CI04-582; No Copyright; Avail: CASI; A03, Hardcopy<br />
Previous studies have suggested an association between ambient airborne particulate matter (PM 10) concentrations <strong>and</strong><br />
adverse ophthalmologic conditions. To determine a correlation between PM 10 <strong>and</strong> Ophthalmologic Disease, Non-battle<br />
Injuries (DNBI), datasets currently available on active duty personnel deployed to a US military base in Central Comm<strong>and</strong><br />
(CENTCOM) were collected <strong>and</strong> analyzed for the period between October 1999 <strong>and</strong> September 2001. Weekly averages of<br />
ophthalmologic, non-ophthalmologic, <strong>and</strong> total DNBI rates were compared to a weekly average PM 10 concentration <strong>and</strong><br />
Pearson’s coefficients were calculated (r =0.00024 with p value = 0.5, r =0.090 with p-value =0.239, <strong>and</strong> r =0.087 with p- value<br />
=0.246, respectively). The extremely low r coefficients indicate that there is no correlation between weekly average PM 10<br />
concentrations <strong>and</strong> weekly average Ophthalmologic Disease, Non-battle Injury Rates at this location. Two conclusions are<br />
suggested: (1) the PMl0 was not at a sufficient or consistently high enough level to affect the eye, or (2) personnel may already<br />
be protecting their eyes by wearing sunglasses <strong>and</strong> goggles or staying indoors when weather conditions are very windy.<br />
DTIC<br />
Air Pollution; Deployment; Diseases; Injuries; Medical Personnel; Ophthalmology; Particles; Personnel<br />
20040111581 Chicago Univ., Chicago, IL<br />
Estrogen Receptor Inhibition of NF- (kappa) B Activity in Breast Cancer<br />
Nettles, Kendall W.; Greene, Geoffrey L.; Jun. 2003; 6 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-01-1-0198<br />
Report No.(s): AD-A425643; No Copyright; Avail: CASI; A02, Hardcopy<br />
Estrogen Receptor-alpha (ER) mediated inhibition of NF-kappaB contributes to the anti- inflammatory <strong>and</strong> protective<br />
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