NASA Scientific and Technical Aerospace Reports

concentrations of: B, Ca, Cd, Se, and Zn; and (3) determination of tissue and cellular distribution of these elements using
NanoSIMS ion microscope at Lawrence Livermore National Laboratory (LLNL). Progress toward specific aim 1 includes
preparing matched samples of normal tissue with graded tumor tissue from pathological tissue at prostatectomy. Progress
toward specific aim 2 includes method development and analysis of 23 paired samples of normal and Gleason graded tumor
tissue. Results were submitted in October for presentation at the April 2004 Experimental Biology Meetings in Washington,
D.C. The data do not support an association between Gleason scores and the elements concentration in prostate tissue, but
show considerable variability in the population. Work toward specific aim 3 has concentrated on methods development for
NanoSIMS ion microscopy. Two students will undergo training at LLNL to become expert in the use of the NanoSIMS ion
microscopy.
DTIC
Cancer; Epidemiology; Nutrition; Prostate Gland; Risk
20040111706 House Ear Inst., Los Angeles, CA
Neurofibromatosis Type 2 (NF2) Natural History Consortium
Slattery, William; Jan. 2004; 11 pp.; In English
Contract(s)/Grant(s): DAMD17-01-1-0710
Report No.(s): AD-A425862; No Copyright; Avail: CASI; A03, Hardcopy
Neurofibromatosis 2 (NF2) is an autosomal disorder characterized by the development of multiple tumors within the brain
and spinal canal. The purpose of the study is to define growth rates and clinical course of tumors associated with NF2. An
international consortium of clinical centers and expertise in NF2 will be developed. We will standardize the volumetric
analysis of intracranial and spinal tumors, and assess the patients’ audiological, neurological, and ophthalmological
functioning over the course of 3 years. Currently, 65 subjects are actively enrolled. Of the subjects that have had their exams,
91% of Year 1 audiological, 93% of cranial MRIs, 91% of spinal MRIs, 90% of neurological, 86% of ophthalmologic, 89%
of SF-36 health surveys and 91% of physical functioning questionnaires have been received. Fifty-four percent of Year 2
audiological, 73% of cranial MRIs, 81% of spinal MRIs, 93% of neurological, 73% of ophthalmologic, 82% of SF-36 health
surveys and 89% of physical functioning questionnaires have been received. Two foreign sites have experienced difficulty
obtaining a Federal-wide assurance number and Army approval for subject enrollment. We have made good progress toward
completion of the study’s goals and anticipate few problems with the collection of Year 3 follow-up data.
DTIC
Brain; Clinical Medicine; Neurology; Ophthalmology; Organizations
20040111707 Fayetteville State Univ., NC
Changing the Attitude and Behaviors of Black Men to Screening for Prostate Cancer
Twum, Maxwell; Mar. 2004; 13 pp.; In English
Contract(s)/Grant(s): DAMD17-00-1-0016
Report No.(s): AD-A425863; No Copyright; Avail: CASI; A03, Hardcopy
The objectives of the project are a) to explore the prevailing attitudes toward screening for prostate cancer among Black
men in the Cape Fear region of North Carolina b) to determine the comparative effectiveness of a one-time presentation of
information advocating prostate cancer screening to that of repeated presentation of the message, and c) to determine the
characteristics and impact of the agent of information delivery on the attitudes and behaviors of Black men toward screening
for prostate cancer. The study involves the presentation of uniform messages advocating the benefits of prostate cancer
screening to a group of 120 Black men 40 years and older who have never screened for prostate cancer, nor participated in
a prostate cancer screening education program. Researchers, health professionals, and peer facilitators will deliver educational
messages once to one group, and three times to a second group. The comparison of attitudes before exposure to the messages
to that after exposure will help determine the impact of the program on attitudes in the groups. The number of men screened
following exposure to the messages will determine the impact of the program on behavior change.
DTIC
Attitude (Inclination); Cancer; Human Behavior; Human Beings; Males; Prostate Gland; Psychology
20040111709 Air Force Inst. of Tech., Wright-Patterson AFB, OH
Staffing Levels and Inpatient Outcomes at Military Health Care Facilities: A Resource-Based View
Yap, Glenn A.; Jan. 2004; 164 pp.; In English
Report No.(s): AD-A425865; CI04-587; No Copyright; Avail: CASI; A08, Hardcopy
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