NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
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L27, <strong>and</strong> human DNA clone RPll-290F20 on chromosome 20. These genes will be further analyzed for their transformation<br />
properties of human mammary epithelial cells as discussed in the<br />
DTIC<br />
Cancer; Genes; Irradiation; Libraries; Mammary Gl<strong>and</strong>s<br />
20040111725 National Academy of Sciences - National Research Council, Washington, DC<br />
Continuation of Support for the Institute for Laboratory Animal Research<br />
Zurlo, Joanne; Jul. 2004; 16 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-03-1-0494<br />
Report No.(s): AD-A425894; No Copyright; Avail: CASI; A03, Hardcopy<br />
ILAR is a recognized leader in developing <strong>and</strong> disseminating guidelines for laboratory animal care, breeding, <strong>and</strong> use.<br />
ILAR develops resources for identifying animal models for human diseases <strong>and</strong> physiological processes; <strong>and</strong> prepares reports<br />
on the humane <strong>and</strong> scientific use of laboratory animals. The program goal is to improve the humane <strong>and</strong> scientifically valid<br />
use of laboratory animals as well as the availability, quality <strong>and</strong> care of laboratory animals. ILAR accomplishes this goal<br />
through a core program, carried out by staff, <strong>and</strong> a special-project program, carried out by National Academies- appointed<br />
experts. Both programs are guided by a 15-member advisory council comprised of experts in laboratory animal medicine,<br />
physiology, genetics, medicine, animal welfare, <strong>and</strong> related biomedical sciences. ILAR Council meets three times a year to<br />
provided program direction <strong>and</strong> strategic planning; to oversee the communication <strong>and</strong> information programs; to oversee<br />
special projects; <strong>and</strong> to direct ILAR’s international programs. All of ILAR’s programs are funded by contracts <strong>and</strong> grants from<br />
various government agencies <strong>and</strong> private organizations including the U.S. Army Medical Research <strong>and</strong> Materiel Comm<strong>and</strong><br />
(USAMRMC). These funds partially support maintenance of the web site, publication of the quarterly ILAR Journal, exhibits<br />
at scientific meetings, work of the Council, <strong>and</strong> general office operations.<br />
DTIC<br />
Animals; Medical Science<br />
20040111726 Massachusetts Univ. Medical Center, Worcester, MA<br />
Role of Chromatin Remodeling by RAD54 in DNA Damage Repair <strong>and</strong> Homologous Recombination<br />
Jaskelioff, Mariela; Peterson, Craig; Apr. 2004; 13 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-02-1-0471<br />
Report No.(s): AD-A425895; No Copyright; Avail: CASI; A03, Hardcopy<br />
Chromatin structure has a strong influence on the regulation of all nuclear processes in which access to DNA is required,<br />
such as transcription, replication <strong>and</strong> DNA repair. We have previously shown that Rad54p, a member of the SWl2/SNF2<br />
family required for the repair of DNA double-str<strong>and</strong> breaks (DSBs) by homology recombination, is a bona fide ATPdependent<br />
chromatin remodeling enzyme, <strong>and</strong> that the ability of Rad54 to modulate chromatin structure is required for the<br />
proper repair of DSBs in a chromatin context. We had previously observed that Rad54p was stabilized against thermal<br />
denaturation by chromatin. Here, we report that this stabilizating effect is real <strong>and</strong> specific, <strong>and</strong> it can be attributed to the ability<br />
of Rad54p to directly interact with the amino-terminal portion of hi stones H3 <strong>and</strong> H4. Interestingly, H3 <strong>and</strong> H4<br />
amino-terminal domains are targets of post-translational modifications required for DNA repair. Particularly, H3 acetylation<br />
by Hatlp, <strong>and</strong> H4 acetylation by Esalp have been shown to be critical steps in the repair of DSBs. We found that even though<br />
Rad54p discriminately binds H3 <strong>and</strong> H4 proximal amino-terminal domains, this interactions are not essential for its ability to<br />
remodel chromatin <strong>and</strong> drive the homologous recombination process in our in vitro setup.<br />
DTIC<br />
Damage; Deoxyribonucleic Acid; Proteins<br />
20040111727 Georgetown Univ., Washington, DC<br />
IKK <strong>and</strong> (Beta)-Catenin in Breast Cancer<br />
Teo, Marissa; Jul. 2003; 116 pp.; In English; Original contains color illustrations<br />
Contract(s)/Grant(s): DAMD17-01-1-0248<br />
Report No.(s): AD-A425896; No Copyright; Avail: CASI; A06, Hardcopy<br />
The Wnt pathway is involved in many differentiation events. Mutations involving downstream components like APC or<br />
b-catenin result in nuclear accumulation of b-catenin, which results in cancer. This project has discovered that cytokine, TNFa<br />
<strong>and</strong> ectodysplasin (Eda) <strong>and</strong> its receptor, Edar regulate b-catenin signaling activity. A conserved sequence, DSGXXS, within<br />
the N-terminus of b-catenin <strong>and</strong> IkappaB, allows for targeted phosphorylation by upstream kinases such as IkappaB kinase.<br />
214
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