NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
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will coordinate <strong>and</strong> implement research programs in cardiovascular disease, cancer, stroke, trauma <strong>and</strong> critical care, that are<br />
supported by basic science <strong>and</strong> engineering development in biomaterials, endoscopic tools, energy delivery, intelligent<br />
decision systems, medical imaging, micro-sensors, outcomes, robotics <strong>and</strong> simulation A unique military/ civilian partnership<br />
fostered by ClMIT will allow DOD technologies to be evaluated by CIMlT investigators <strong>and</strong> facilitate the transfer to the<br />
military of successful minimally invasive approaches developed at CIMIT. An educational program, which includes<br />
coursework, seminars, <strong>and</strong> on-site training opportunities, will serve the shared needs of academic <strong>and</strong> military physicians <strong>and</strong><br />
scientists. The overall goal of CIMIT is to create a national program that combines clinical <strong>and</strong> technological excellence in<br />
order to generate, develop, <strong>and</strong> reduce-to-practice innovative <strong>and</strong> high-impact concepts in minimally invasive therapy.<br />
DTIC<br />
Medical Science; Therapy<br />
20040111661 Pennsylvania Univ., Philadelphia, PA<br />
Genetic Counseling for Breast Cancer Susceptibility in African American Women<br />
Hughes, Chanita M.; Feb. 2004; 74 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-00-1-0262<br />
Report No.(s): AD-A425772; No Copyright; Avail: CASI; A04, Hardcopy<br />
Increasingly, the cultural beliefs <strong>and</strong> values of participants are being recognized as important factors in genetic counseling.<br />
Despite recommendations to increase the cultural sensitivity of genetic counseling, such programs have not been developed<br />
or evaluated. The objectives of this study are to develop a Culturally Tailored Genetic (CTGC) protocol for African American<br />
women <strong>and</strong> evaluate its impact on decision- making <strong>and</strong> satisfaction about BRCAl/2 testing, quality of life, <strong>and</strong> cancer control<br />
practices. A secondary objective of this study is to identify African American women who are most <strong>and</strong> least likely to benefit<br />
from CTGC vs. SGC. The key research accomplishments achieved during the past year include finalizing the culturally<br />
tailored genetic counseling protocol <strong>and</strong> initialing subject recruitment.<br />
DTIC<br />
Africa; Cancer; Females; Genetics; Mammary Gl<strong>and</strong>s<br />
20040111662 Baylor Coll. of Medicine, Houston, TX<br />
Biochemical Analysis of the BRCA2 Protein Complex<br />
Qin, Jun; Apr. 2004; 51 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-00-1-0146<br />
Report No.(s): AD-A425776; No Copyright; Avail: CASI; A04, Hardcopy<br />
This linked career development award <strong>and</strong> idea award (CDA part) aims at relieving my administrative duties to acquire<br />
molecular biology skills in biology research. I have learned all the molecular biology techniques in accordance to Task 1 <strong>and</strong><br />
2 as stated in the Statement of Work. I have also learned biochemistry <strong>and</strong> cell biology techniques including protein complex<br />
purification, indirect immuno-staining <strong>and</strong> functional assays for activation of the S-phase <strong>and</strong> 02/M checkpoints. This career<br />
development award has allowed me to finish the transition from a mass spectrometrist who concentrates on methodology<br />
development to a biologist who works on important problems that are related to breast cancer <strong>and</strong> other human disease. During<br />
the award period, I have published 5 papers as a corresponding author <strong>and</strong> many papers as a collaborator. I have obtained 3<br />
RO1 grants from NIH to study the molecular mechanism of DNA damage checkpoint activation, which is important for<br />
suppression of breast cancer development.<br />
DTIC<br />
Biochemistry; Cancer; Chemical Analysis; Mammary Gl<strong>and</strong>s; Proteins<br />
20040111663 Fox Chase Cancer Center, Philadelphia, PA<br />
TSC1 <strong>and</strong> TSC2 Gene Homologs in Schizosaccharomyces Pombe<br />
Henske, Elizabeth; Apr. 2004; 16 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-03-1-0252<br />
Report No.(s): AD-A425777; No Copyright; Avail: CASI; A03, Hardcopy<br />
This project is focused on the TSCl <strong>and</strong> TSC2 gene homologs in the fission yeast Schizosaccharomyces pombe (S.<br />
pombe). Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disease whose manifestations can include<br />
seizures, mental retardation, autism, <strong>and</strong> tumors of the brain, heart, kidney <strong>and</strong> skin. The TSC2 gene encodes tuberin, a 200<br />
kD protein with homology to GTPase activating protein (GAP) for Rap 1. The TSCl gene encodes hamartin, a 130 kD protein.<br />
Both TSC genes are tumor suppressor genes: germline TSCl <strong>and</strong> TSC2 mutations are predicted to inactivate protein function,<br />
200
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