NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
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ecognized <strong>and</strong> bound to bacterial cell surfaces. Results presented here demonstrate the existence of a novel MUC1 protein<br />
isoform. MUC1/ZD, expressed in breast cancer <strong>and</strong> skin epithelial cells that participates in bacterial recognition.<br />
DTIC<br />
Cancer; Epithelium; Genes; Mammary Gl<strong>and</strong>s<br />
20040111690 Clarian Health Partners, Inc., Indianapolis, IN<br />
Summer Student Breast Cancer Research Training Program<br />
Zaloga, Gary P.; May 2004; 58 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-03-1-0338<br />
Report No.(s): AD-A425839; No Copyright; Avail: CASI; A04, Hardcopy<br />
The purpose of the breast cancer research-training program is to recruit <strong>and</strong> train potential future researchers in breast<br />
cancer research. We recruited 15 individuals, interviewed eight, <strong>and</strong> chose five for the program. During the 12-week program,<br />
trainees attended seven lectures dealing with research, participated in weekly research meetings, <strong>and</strong> developed <strong>and</strong> carried<br />
out separate research projects under the supervision of their rese%rch mentors. Two projects involved study of the anticancer<br />
properties of Ganoderma lucidium-(GL), a medicinal mushroom. GL was found to inhibit estrogen receptor signaling in breast<br />
cancer cells. Two projects studied the effects of omega-3 long chain polyunsatureated fatty acids (O3FA). O3FA (notably<br />
methyl esters of the lipids) were found to inhibit proliferation of an proteolysis induced by breast cancer cells. A fifth project<br />
evaluated the effect of C-reative protein (CRP), an important inflammatory molecule upon protein markers of cancer<br />
invasiveness. CRP was found to stimulate expression of urokinase plasminogen activator <strong>and</strong> its receptor. These results<br />
provide the basis for ongoing research projects. The results have added significant new information to our underst<strong>and</strong>ing of<br />
dietary modulation of breast cancer cell proliferation <strong>and</strong> invasion <strong>and</strong> provide a basis for further studies of dietary modulation<br />
of breast cancer.<br />
DTIC<br />
Cancer; Education; Mammary Gl<strong>and</strong>s; Medical Science; Research; Students; Summer<br />
20040111691 North Carolina Univ., Chapel Hill, NC<br />
The Role of Nuclear Receptor Coactivators in Recurrent Prostate Cancer<br />
Gregory, Christopher W.; Feb. 2004; 31 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-02-1-0110<br />
Report No.(s): AD-A425840; No Copyright; Avail: CASI; A03, Hardcopy<br />
The hypothesis for this proposal is that in a substantial number of recurrent prostate cancers, growth is driven by the<br />
overexpression of steroid receptor coactivators SRC1 <strong>and</strong> TlF2 through their effects on AR-mediated gene expression.<br />
Completion of the studies proposed will elucidate the role of nuclear receptor coactivators in the progression of prostate cancer<br />
from the <strong>and</strong>rogen-dependent to the recurrent state. We will test the hypothesis that recurrent prostate cancer growth is driven<br />
by the overexpression of coactivators SRCl <strong>and</strong> TIF2 through their effects on AR- mediated gene expression. By completing<br />
studies on coactivator expression in prostate cancer specimens, coactivator phosphorylation <strong>and</strong> the kinase signaling pathways<br />
responsible, we will establish a link between AR function as a part of the transcription complex <strong>and</strong> cell growth in recurrent<br />
prostate cancer.<br />
DTIC<br />
Cancer; Hormones; Males; Prostate Gl<strong>and</strong>; Receptors (Physiology)<br />
20040111692 Winston-Salem State Univ., Winston-Salem, NC<br />
Developing a Training Program in Breast Cancer Research to Decrease the Disparity of Morbidity <strong>and</strong> Mortality in<br />
Underserved/Minority Women<br />
Flack, Sylvia A.; Oct. 2003; 67 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-01-1-0458<br />
Report No.(s): AD-A425841; No Copyright; Avail: CASI; A04, Hardcopy<br />
Winston-Salem State University (WSSU) a designated Historically Black College <strong>and</strong> University (HBCU) is committed<br />
to resolving some of the economic, social <strong>and</strong> health problems in the community in which the university is located. Breast<br />
cancer deaths <strong>and</strong> complication occur disproportionately in minority women than majority women within this community. This<br />
proposal is designed to develop a sustainable breast cancer training program at WSSU. Four faculty post docs from the School<br />
of Health Sciences are developing research skills by engaging in breast cancer research with professors at Johns Hopkins<br />
University who are experts in this area. In order to accomplish this project an interdisciplinary committee of doctors, nurses,<br />
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