NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
NASA Scientific and Technical Aerospace Reports
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family receptors could elicit alternatively the differentiation or proliferation of breast cancer cells. These experiments were<br />
thwarted by an inability of cultured cell models to consistently show heregulin-induced differentiation. Subsequently, we<br />
addressed the mechanism of activation of mitogen-activated protein kinase (MAPK) by heregulin coreceptors in breast cancer<br />
cells. Interestingly, we observed that inhibitors of the phosphoinositide (PI) 3- kinase signaling pathway blocked the nuclear<br />
translocation of MAPK. These findings indicated a point of significant cross- talk between two major signaling pathways<br />
activated by heregulin receptors. In our most recent experiments, we examined the dynamics of the ErbB1 (EGF receptor)<br />
C-terminal domain, by generating fluorescently labeled EGF receptor proteins. Time-resolved fluorescence anisotropy<br />
measurements indicated that the C-terminal domain exhibited significant mobility on the nanosecond time-scale.<br />
DTIC<br />
Cancer; Mammary Gl<strong>and</strong>s; Peptides<br />
20040111737 Oregon Research Inst., Eugene, OR<br />
Population Health Trial for Smokeless Tobacco Cessation With Military Personnel<br />
Severson, Herbert H.; May 2004; 72 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-02-2-0017<br />
Report No.(s): AD-A425921; No Copyright; Avail: CASI; A04, Hardcopy<br />
While smoking cessation has received considerable attention within the military, the use of smokeless tobacco (chewing<br />
tobacco <strong>and</strong> snuff) has not been a focus of medical services or research. Epidemiological data suggest that while smoking has<br />
continued to decline both in the general population <strong>and</strong> within the military, the use of smokeless tobacco products has<br />
increased. The primary objective of this research is to develop <strong>and</strong> evaluate an intervention for smokeless tobacco cessation<br />
comprised of proactive recruitment, targeted written <strong>and</strong> video materials mailed to the participant, <strong>and</strong> phone call support. At<br />
the end of this second year of the study, several accomplishments have been achieved. Accomplishments include: completion<br />
of all the materials being used in the intervention, including a cessation manual <strong>and</strong> video tailored to military personnel; hiring<br />
<strong>and</strong> training of motivational telephone counselors; initiated formal enrollment of participants at eleven dental clinics across<br />
nine military sites; <strong>and</strong> completion of IRB review by Naval Hospital <strong>and</strong> Walter Reed Medical Center.<br />
DTIC<br />
Health; Military Personnel; Populations; Tobacco<br />
20040111739 Ohio State Univ., Columbus, OH<br />
Soy Supplementation <strong>and</strong> Prostate Cancer Prevention<br />
Paskett, Electra D.; Mar. 2004; 5 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-99-1-9467<br />
Report No.(s): AD-A425923; No Copyright; Avail: CASI; A01, Hardcopy<br />
This project is conducting a r<strong>and</strong>omized double- blind clinical trial to access the ability of a soy protein dietary<br />
supplement to reduce prostate cancer risk in older men. A total of 120 men (60 white <strong>and</strong> 60 African-American) aged 50 years<br />
or older with high PSA levels but normal prostate biopsies will be r<strong>and</strong>omized into one of two groups (soy protein<br />
supplementation with isoflavones or casein protein supplementation). The specific aims are: 1) to determine the impart of the<br />
interventions, including changes in clinical (PSA levels <strong>and</strong> prostate volume) <strong>and</strong> intermediate (Ki-67, apoptosis, sex-steroid<br />
receptors, angiogenesis, antioxidant enzyme expression) markers of prostate cancer risk; 2) to assess soy protein effects on<br />
hormone levels, plasma lipids/kipoproteins <strong>and</strong> blood pressure; <strong>and</strong> 3) to evaluate changes in health-related quality of life,<br />
including urinary symptoms <strong>and</strong> sexual functioning. This project involves a multidisciplinary team affiliated with the<br />
oncology, Epidemiology, health-related quality of life, biostatistics, <strong>and</strong> nutrition. NCI approval of the CALGB protocol<br />
delayed start-up of this study; recruitment has been continuous since March 2000. However, recruitment to this study was<br />
suspended during the previous reporting time period per DOD Human Subjects Protection Office. Currently the study is open<br />
at 13 Cancer <strong>and</strong> Leukemia Group B sites.<br />
DTIC<br />
Cancer; Prevention; Prostate Gl<strong>and</strong>; Proteins<br />
20040111740 British Columbia Cancer Agency, Vancouver, British Columbia<br />
A Genomic Approach to Identifying Novel Targets for Early Detection <strong>and</strong> Intervention of Prostate Cancer<br />
Lam, Wan L.; Sep. 2003; 19 pp.; In English<br />
Contract(s)/Grant(s): DAMD17-01-1-0028<br />
Report No.(s): AD-A425926; No Copyright; Avail: CASI; A03, Hardcopy<br />
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