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Encyclopedia of Health and Medicine

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irth defects 11<br />

COMMON TERATOGENIC MEDICATIONS<br />

Medication Taken to Treat Kinds <strong>of</strong> Birth Defects<br />

Pregnancy Category X Medications<br />

antimetabolitic CHEMOTHERAPY CANCER crani<strong>of</strong>acial anomalies, anencephaly,<br />

drugs (aminopterin, cytarabine,<br />

absence <strong>of</strong> kidneys, HEART malformations<br />

methotrexate, methyl aminopterin)<br />

risk highest in first trimester<br />

danazol (Danocrine) ENDOMETRIOSIS, FIBROCYSTIC BREAST PSEUDOHERMAPHRADITISM<br />

DISEASE, hereditary ANGIOEDEMA<br />

finasteride (Propecia, Proscar) male pattern baldness (Propecia), malformation <strong>of</strong> male GENITALIA<br />

BENIGN PROSTATIC HYPERTROPHY (BPH)<br />

(Proscar)<br />

pregnant women are at risk if they<br />

h<strong>and</strong>le the pills<br />

flurazepam (Dalmane) SLEEP DISORDERS isolated cleft palate<br />

lovastatin (Mevacor) HYPERLIPIDEMIA SPINA BIFIDA<br />

retinoic acid, isotretinoin severe ACNE crani<strong>of</strong>acial anomalies, heart malformations,<br />

(Accutane)<br />

limb deformities, LIVER malformations<br />

highest risk in early first trimester<br />

temazepam (Restoril) sleep disorders isolated cleft palate<br />

triazolam (Halcion) sleep disorders isolated cleft palate<br />

thalidomide (Thalomid, Synovir) HANSEN’S DISEASE (leprosy), severely shortened or missing long bones in<br />

AIDS-related wasting disease<br />

the arms <strong>and</strong> legs<br />

(cachexia)<br />

warfarin (Coumadin) blood clots (preventive) constellation <strong>of</strong> birth defects commonly<br />

referred to as fetal warfarin syndrome<br />

multiple skeletal deformities <strong>and</strong><br />

malformations occur with exposure in early<br />

first trimester<br />

CENTRAL NERVOUS SYSTEM damage occurs with<br />

exposure in second <strong>and</strong> third trimesters<br />

Pregnancy Category D Medications<br />

angiotensin-converting enzyme HYPERTENSION KIDNEY deformities or absence <strong>of</strong> kidneys, limb<br />

(ACE) inhibitor medications<br />

contractures, patent ductus arteriosus (PDA)<br />

(benazepril, captopril, enalapril,<br />

risk highest in second <strong>and</strong> third trimesters<br />

fosinopril, lisinopril, moexipril,<br />

ramipril, tr<strong>and</strong>olapril)

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