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Encyclopedia of Health and Medicine

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416 Appendix VII<br />

tional st<strong>and</strong>ards <strong>and</strong> racial discrimination in combination<br />

proved too formidable for Thomas to follow<br />

his dream. Blalock nonetheless insisted that<br />

Thomas assist him in the operating room, <strong>and</strong><br />

<strong>of</strong>ten Thomas guided Blalock through difficult<br />

aspects <strong>of</strong> the operations Thomas devised.<br />

van Leeuwenhoek, Antonie (1632–1723)<br />

Dutch amateur scientist who built his own microscopes.<br />

His studies were among the earliest to<br />

detail the structures <strong>and</strong> functions <strong>of</strong> blood cells,<br />

bacteria, <strong>and</strong> sperm. The work <strong>of</strong> van Leeuwenhoek<br />

also established the role <strong>of</strong> bacteria in causing<br />

illness, providing the foundation for the<br />

research more than a century later <strong>of</strong> Robert Koch<br />

<strong>and</strong> Joseph Lister.<br />

Vesalius, Andreas (1514–1564) Flemish<br />

anatomist whose book De Humanis Corporis Fabrica<br />

(On the Workings <strong>of</strong> the Human Body) was the foundation<br />

<strong>of</strong> human anatomy for centuries. Through a<br />

friendship with a judge, Vesalius gained access to<br />

the bodies <strong>of</strong> executed criminals for dissection.<br />

Many <strong>of</strong> Vesalius’s discoveries contradicted the<br />

teachings <strong>of</strong> Galen, still popular at the time. Key<br />

among them were that the heart had four chambers,<br />

not two as Galen asserted, <strong>and</strong> that the major<br />

blood vessels arose from the heart, not the liver.<br />

Vesalius also provided correct <strong>and</strong> detailed drawings<br />

<strong>of</strong> the gastrointestinal structures.<br />

von Behring, Emil Adolf (1854–1917) Prussian<br />

physician whose research on toxins <strong>and</strong> antitoxins<br />

led to the development <strong>of</strong> tetanus <strong>and</strong><br />

diphtheria vaccines, established the foundation for<br />

serum therapy, <strong>and</strong> earned the first Nobel Prize for<br />

Physiology or <strong>Medicine</strong> awarded in 1901.<br />

Waksman, Selman (1888–1973) Biochemist<br />

who discovered the antibiotic medications streptomycin,<br />

the first antibiotic effective for treating<br />

tuberculosis, <strong>and</strong> neomycin. Waksman received<br />

the 1952 Nobel Prize in Physiology or <strong>Medicine</strong> in<br />

recognition <strong>of</strong> his work.<br />

Watson, James (b. 1928) American scientist<br />

who co-discovered, in collaboration with British<br />

researcher Francis Crick, the double helix structure<br />

<strong>of</strong> DNA in 1953. Watson <strong>and</strong> Crick shared the<br />

1962 Nobel Prize in Physiology or <strong>Medicine</strong> for<br />

their work. Watson conducted much research on<br />

the role <strong>of</strong> RNA in viruses <strong>and</strong> served as director<br />

<strong>of</strong> the Human Genome Project from 1989 to 1992.<br />

He wrote several books, among them the 1968<br />

best-seller Double Helix, which chronicled the discovery<br />

<strong>of</strong> DNA.<br />

Yalow, Rosalyn (b. 1921) American physicist<br />

who developed techniques to use radioisotopes to<br />

measure the amount <strong>of</strong> peptide hormones such as<br />

insulin in the blood, which are present in very<br />

small quantities. These techniques became known<br />

as radioimmunoassays (RIAs) <strong>and</strong> are today the<br />

basis for such measurements. Yalow received a<br />

share <strong>of</strong> the Nobel Prize in Physiology or <strong>Medicine</strong><br />

in 1977 for her work.

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