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Encyclopedia of Health and Medicine

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426 Appendix XII<br />

Year Laureate(s) Discovery<br />

1998 Robert F. Furchgott (b. 1916; USA) role <strong>of</strong> nitric oxide in the functions <strong>of</strong> the heart <strong>and</strong> blood vessels<br />

Louis J. Ignarro (b. 1941; USA)<br />

Ferid Murad (b. 1936; USA)<br />

1997 Stanley B. Prusiner (b. 1942; USA) infectious prions<br />

1996 Peter C. Doherty (b. 1940; Australia) mechanisms through which the immune system recognizes <strong>and</strong> attempts<br />

Rolf M. Zinkernagel (b. 1944; Switzerl<strong>and</strong>) to contain cells infected with viruses<br />

1995 Edward B. Lewis (1918–2004; USA) mechanisms through which genes control the development <strong>of</strong> cells <strong>and</strong><br />

Christiane Nüsslein-Volhard (b. 1942; tissues into specialized structures <strong>and</strong> organs in the embryo<br />

Germany)<br />

Eric F. Wieschaus (b. 1947; USA)<br />

1994 Alfred G. Gilman (b. 1941; USA) G-proteins, which regulate how cells receive <strong>and</strong> use other protein<br />

Martin Rodbell (1925–1998; USA)<br />

signals<br />

1993 Richard J. Roberts (b. 1943; UK) split, or segmented, genes<br />

Phillip A. Sharp (b. 1944; USA)<br />

1992 Edmond H. Fischer (b. 1920; USA) roles <strong>of</strong> the enzymes kinase <strong>and</strong> phosphatase to attach <strong>and</strong> remove<br />

Edwin G. Krebs (b. 1918; USA)<br />

molecules for energy (glucose) release <strong>and</strong> storage<br />

1991 Erwin Neher (b. 1944; Germany) single ion channels <strong>and</strong> their functions in cell electrical activity<br />

Bert Sakmann (b. 1942; Germany)<br />

1990 Joseph E. Murray (b. 1919; USA) organ transplantation to treat diseases such as kidney failure <strong>and</strong> heart<br />

E. Donnall Thomas (b. 1920; USA) failure, including management <strong>of</strong> the immune response to prevent<br />

organ rejection <strong>and</strong> host vs. graft disease<br />

1989 J. Michael Bishop (b. 1936; USA) origin <strong>of</strong> oncogenes is within cells that become cancerous<br />

Harold E. Varmus (b. 1939; USA)<br />

1988 Sir James W. Black (b. 1924; UK) Black: mechanisms by which drugs are effective in treating diseases<br />

Gertrude B. Elion (1918–1999; USA)<br />

such as heart disease <strong>and</strong> cancer<br />

George H. Hitchings (1905–1998; USA) Elion <strong>and</strong> Hitchings: mechanisms <strong>of</strong> RNA function resulting in new<br />

drugs to treat various diseases such as leukemia, malaria, <strong>and</strong> organ<br />

rejection after transplantation<br />

1987 Susumu Tonegawa (b. 1939; Japan) role <strong>of</strong> genes in the production <strong>and</strong> function <strong>of</strong> antibodies<br />

1986 Stanley Cohen (b. 1922; USA) nerve growth factor (NGF) <strong>and</strong> epidermal growth factor (EGF),<br />

Rita Levi-Montalcini (b. 1909; Italy)<br />

substances that regulate cell growth <strong>and</strong> differentiation<br />

1985 Michael S. Brown (b. 1941; USA) mechanisms that regulate cholesterol metabolism<br />

Joseph L. Goldstein (b. 1940; USA)

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