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Encyclopedia of Health and Medicine

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Zollinger-Ellison syndrome 95<br />

Though gastrinomas are noncancerous, they <strong>of</strong>ten<br />

spread to other locations (notably the LIVER) <strong>and</strong><br />

may develop into CANCER over time. Doctors do<br />

not know what causes Zollinger-Ellison syndrome<br />

though it appears to have a correlation with MULTI-<br />

PLE ENDOCRINE NEOPLASIA (MEN) type 1, a disorder in<br />

which tumors (including gastrinomas) develop in<br />

numerous endocrine gl<strong>and</strong>s.<br />

The symptoms <strong>of</strong> Zollinger-Ellison syndrome<br />

are the same as those for peptic ulcer disease (DYS-<br />

PEPSIA, NAUSEA, sensation <strong>of</strong> fullness, possible GAS-<br />

TROINTESTINAL BLEEDING). ENDOSCOPY <strong>of</strong> the upper<br />

gastrointestinal tract may reveal gastrinomas in<br />

the duodenum. Abdominal ULTRASOUND, COMPUTED<br />

TOMOGRAPHY (CT) SCAN, or MAGNETIC RESONANCE<br />

IMAGING (MRI) can detect gastrinomas in the pancreas<br />

or the duodenum. Treatment combines medication<br />

to reduce gastric acid production, such as<br />

H2 ANTAGONIST (BLOCKER) MEDICATIONS or PROTON<br />

PUMP INHIBITOR (PPI) MEDICATIONS, <strong>and</strong> surgery to<br />

remove or reduce the gastrinomas when possible.<br />

See also CANCER RISK FACTORS; CANCER PREVENTION;<br />

LIVER CANCER; PANCREATIC CANCER; PANCREATITIS;<br />

STOMACH CANCER.

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