Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
______________________________________________________________________________
Type: other
Species: rat
Sex: male
No. of Animals: 6
Exposure time: 4 hour(s)
Value: < 16000 ppm
Method: other
GLP: no data
Test substance: no data
Remark: Four of the six males died following exposure to 16000 ppm
(52.2 mg/l). Five minutes were stated as the maximum time of
concentrated vapour inhalation without deaths. No more data
were given.
Groups of six males; observed for 14 days.
Source: BP Chemicals Ltd LONDON
Deutsche Shell Chemie GmbH Eschborn
German rapporteur
Flag: Risk Assessment
07–JUL–2005 (1062)
Type: LC50
Species: mouse
No. of Animals: 182
Doses: 4980, 7490, 8330, 9280, 10200, 10450, 10950, 11540, 12430,
14600 ppm (15.9, 23.9, 26.6, 29.6, 32.2, 33.3, 34.9, 36.8,
39.6, 46.5 mg/l)
Exposure time: 7 hour(s)
Value: = 10400 ppm
Method: other
GLP: no data
Test substance: other TS: purity 99.5%
Remark: method: male and female Swiss mice, concentration analysed
by interferometric determination, 16–20 mice per group, 10
concentrations tested, post exposure observation period up
to 4 weeks but deaths occurred mostly within 8 h after start
of exposure.
results: LC50 after 1 h post exposure observation period 10400
ppm, converted to 31.79 mg/l; 95% confidence limits
9180–10860ppm; symptoms: restlessness, tremor, muscular
twitching,S–shaped tail, changes in respiration,
incoordination,narcosis; histopathology: congestion of lungs
and kidneys,nuclear fragments in spleen follicles.
Reliability: 1
Comparable to guideline study
LC50 not determined for each sex
Source: Deutsche Shell Chemie GmbH Eschborn
German rapporteur
Flag: Risk Assessment
07–JUL–2005 (1102)
Appendix D: Benzene SIDS Dossier
– 341/957 –