Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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further data) and adjusted, 10% variation.
Result: Unspecified histopathological changes in the kidney, testes
and blood (including leucopenia) were reported.
Source: Deutsche Shell Chemie GmbH Eschborn
Test substance: 99.98% pure.
06–JAN–1997 (1264)
Species: rabbit Sex: female
Strain: New Zealand white
Route of administration: s.c.
Exposure period: 10 days
Frequency of treatment: once daily
Post exposure period: up to 40 days
Doses: 0, 0.25, 0.5 ml/kg bw/day (converts to 0, 219.5, 439
mg/kg bw/day); 6, 8 and 9 rabbits/dose, respectively
Control Group: yes, concurrent vehicle
Method: other
GLP: no data
Test substance: other TS
Remark: Benzene administered as a 50% (v/v) solution in corn oil.
Blood was collected from the middle ear artery at different
intervals (day 0 and 1–40).
Reliability: 3 (not valid)
Unsuitable test system
only effects on lymphocytes studied, no other toxicological
effects reported
Result: A dose– and time–dependent decrease in circulating
lymphocytes (80% reduction in the high dose group,35% at
0.25 ml/kg) which partially recovered 30 days after
treatment, was noted. Circulating monocytes were
significantly decreased in the top–dosed animals at day 10.
Immunoglogin surface receptor–negative cells (presumably
T–lymphocytes) were relatively unaffected.
Source: Deutsche Shell Chemie GmbH Eschborn
Test substance: Laboratory reagent grade benzene, thiophene–free, checked by
GCMS
06–JAN–1997 (568)
Appendix D: Benzene SIDS Dossier
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