Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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Type: Dominant lethal assay
Species: rat Sex: male
Strain: no data
Route of admin.: i.p.
Exposure period: not given
Doses: 0.5 ml/kg bodyweight
Result: negative
Method: other
Year: 1975
GLP: no data
Test substance: no data
Source: German rapporteur
Flag: Risk Assessment
16–AUG–2000 (715)
Type: other
Species: mouse Sex: male
Strain: other
Route of admin.: i.p.
Exposure period: 5 days
Doses: 0.4– 1.0 ml/kg bw/day
Result: positive
Method: other
Year: 1980
GLP: no data
Test substance: no data
Method: sperm abnormality test with (CBA x BALB/c) F1 mice
Source: BP Chemicals Ltd LONDON
German rapporteur
Test substance: Laboratory reagent grade; purity not specified.
Flag: Risk Assessment
21–AUG–2000 (1146)
Type: Cytogenetic assay
Species: mouse Sex: male/female
Strain: other
Route of admin.: gavage
Exposure period: 24 hours
Doses: 0, 10.2, 25.6, 64, 160, 400, 2500 µl/kg bw/day (converts to 0,
8.96, 22.5, 56.3, 140, 352, 2198 mg/kg bw/day)
Method: other
GLP: no data
Test substance: other TS
Remark: 813: reason why not..
Benzene was administered in peanut oil. Groups of ten male
and ten female Swiss Lane Petter mice were exposed to each
benzene dose. Control animals received peanut oil. The
animals were given two administrations, of the same benzene
dose, at 24–hour intervals. Animals received an
intraperitoneal injection of colchicine 3 hours after the
second dose and were killed 3 hours later. The femurs were
Appendix D: Benzene SIDS Dossier
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