Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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and lymphocyte counts were depressed at 25 ppm and higher.
No effect on the granulocytes was seen in all dose groups.
Hemosiderin deposits in the spleen were reported in exposed
animals, however no exact data are available.
Source: German Rapporteur
Flag: Risk Assessment
06–JUL–2005 (261)
Species: mouse Sex: male
Strain: other: C57B1/6J and Swiss Webster
Route of administration: inhalation
Exposure period: 2 wk
Frequency of treatment: 6 h/d, 4 d/wk
Doses: 300 ppm (960 mg/m³)
Control Group: yes
LOAEL: 300 ppm
Method: other
Method: Male mice of each strain were exposed to 300 ppm benzene
(960 mg/m³) for 6 hours per day, 4 days per week, for 2
weeks.
Result: Indicating strain–specific differences in the response to
benzene, susceptiblity was higher in Swiss Webster mice than
in C57B1/6J mice. They had reduced numbers of bone marrow
cells and a reduced development of CFU–E (colony–forming
unit–erythroid) with a more severe reduction in the Swiss
Webster mice.
Source: German Rapporteur
Flag: Risk Assessment
25–OCT–2000 (822)
Species: mouse Sex: male
Strain: other: C57B1/6
Route of administration: inhalation
Exposure period: up to 6 wk
Frequency of treatment: 6 h/d, 5 d/wk
Doses: 1000, 2000, 4000 ppm
Control Group: yes
LOAEL: 1000 ppm
Method: other
Method: 6 males/group
Result: Intermittent exposures of 6 males/group on 5 days per week,
6 hr/day for up to 6 weeks resulted in a
concentration–related leukopenia at dosages of 1000, 2000,
and 4000 ppm. Decreased numbers of white blood cells were
evident on the third day and reached the minimal number by
the 5th or 6th day of exposure. Mortality from continuouing
the treatment up to 6 weeks was negligible. Mice of the 4000
ppm group experienced tremulousness and were nearly
immobilized during the 6–h exposure. Animals recovered
quickly after the return to room air. Differential blood
counts performed on the high dose animals after counts
stabilized during treatment revealed decreased numbers of
lymphocytes (1.34x versus 5.94x10³/cells/µl in controls) and
Appendix D: Benzene SIDS Dossier
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