Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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individual susceptibility; safe workplace exposure limits
for benzene –– ~1 ppm); other malignancies due to benzene
––malignant lymphoma, multiple myeloma, lung cancer.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (14)
Remark: This is a review of hematotoxic and carcinogenic properties
of benzene, supplemented with a summary of case or series
findings from the author’s patients. The suggested effects
of benzene exposure and topics discussed include: aplastic
anemia or pancytopenia; benzene – hepatitis – aplastic
anemia syndrome; leukemia; leukemia in pancytopenia
patientswith chronic benzene toxicity; genetic
relationships
and individual susceptibility in leukemia; other cancers ––
malignant lymphomas, multiple myeloma, lung cancer. The
conclusions of the author are suggestive rather than
definitive.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (16)
Remark: This is a nested case–control study of lymphocytic
leukemia.The 15 cases and 30 matched controls were
identified from a cohort of rubber workers. Potential for
exposure to benzenewas based on occupational titles and
types of solvents used from records of product
specifications and standard operating procedures. Cases
were 4.5 times more likely thancontrols to have had direct
exposure to benzene and other solvents. Cases were 6.7
times more likely than controls tohave been exposed to
coal–based solvents, and 1.5 times morelikely than controls
to have been exposed to petroleum–basedsolvents.
Coal–based
xylene appeared more potent than coal–based benzene with
odds ratios of 5.5 and 3.0, respectively.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (45)
Remark: Mortality among more than 15,000 male employees of the
Australian petroleum industry was examined from 1981 to
1989. All employees had at least 5 years of employment in
the industry. Standardized mortality ratio (SMR) analysis
indicated total cancer mortality was slightly lower
comparedwith the national population. However, mortality
due to lymphohematopoietic cancers, primarily leukemia
(SMR=1.6; 95% confidence interval [CI] 0.6–3.4), was
elevated, but this finding was not statistically
significant. Mortality due to cancers of the pleura was
also elevated (SMR=3.9; 95%CI=0.8–11.0), although two of
the
three cases were likely exposed to asbestos during
employment in other industries.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (203)
Appendix D: Benzene SIDS Dossier
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