Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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abortion.
Source: EXXON Biomedical Sciences East Millstone, NJ
Reliability: (2) valid with restrictions
02–NOV–1998 (1288)
Remark: Re: Benzene and the dose–related incidence of hematologic
neoplasms in China [letter; comment].
Summary (no abstract): A study by Hayes et al of Chinese
workers exposed to benzene and other chemicals noted an
increased NHL risk of 3.0 (95% CI 0.9–10.5). In this letter
to the editor, Otto Wong presents additional unpublished
results from two earlier published studies; a chemical
plant
mortality study and a rubber manufacture mortality
(Pliofilm) study. These earlier studies had not identified
NHL cases specifically. In the reanalysis of the chemical
workers study, there were 7 cases of NHL, with 5.12
expected
(SMR 1.37 95% CI 0.55–2.82). In the rubber study, there
were
3 NHL deaths and 3.28 expected (SMR 0.91 95% CI 0.19–2.66).
He suggests that these results, as well as those from the
published literature support no effect on NHL from benzene
exposure.
Source: EXXON Biomedical Sciences East Millstone, NJ
Reliability: (4) not assignable
02–NOV–1998 (1273)
Remark: ABSTRACT: Objectives: The role of occupational exposures in
hairy cell leukaemia was investigated through a
multicentre,
hospital based, case–control study. This paper analyses the
role of exposure to solvents other than benzene in hairy
cell leukaemia. Methods: The study included 226 male cases
and 425 matched controls. Exposure to solvents was
evaluated
by expert case by case review of the detailed data on
occupational exposures generated by specific interviews.
Also, exposure to solvents was evaluated with an
independently constructed job exposure matrix (JEM).
Results: No association was found between hairy cell
leukaemia and previous employment in a job exposed to
solvents (odds ratio (OR) 0.9 95% confidence interval (95%
CI) 0.6 to 1.3). ORs for the main occupational tasks
exposed
to solvents were around 1 and did not increase with the
frequency or the duration of the tasks. No specific type of
paint or glue was found to be significantly associated with
hairy cell leukaemia. No association was found with
exposure
to solvents, taken as a whole, with either expert
assessments or the JEM. No association was found with
aromatic, chlorinated, or oxygenated subgroups of solvents.
The ORs did not increase with the average intensity of
exposure assessed by the experts, with the frequency of
Appendix D: Benzene SIDS Dossier
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