Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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Type: other: Biological monitoring of benzene in residents living
near petrochemical industrial areas in Korea.
Remark: Residents who live near petrochemical industrial areas risk
exposure to a variety of petrochemicals, including benzene
and benzene–containing liquids. It is a serious concern
because benzene is a human carcinogen naturally present in
petroleum and gasoline. The aim of this study was to assess
the exposure to benzene, measured by personal/indoor/outdoor
air sampling, and to estimate the relationship between the
air samples and biological monitoring data. Through
biological monitoring, the authors investigated
s–phenylmercapturic acid (s–PMA), minor urinary metabolites
of benzene, and benzene in blood. The external benzene
exposure of 115 subjects was measured with passive
dosimeters and urinary s–PMA and blood–benzene were
determined by GC/MS. The mean concentration of benzene in
the breathing zone of residents was 6.3 microgram/m3,
slightly higher than indoor or outdoor concentrations
Personal, indoor and outdoor concentrations of benzene were
significantly correlated to each other. S–PMA was affected
by personal exposure (p < 0.05) and was differed according
to age (p < 0.05) and residence time (p < 0.05). Blood
benzene was not affected by external benzene during these
periods.
Source: EXXON Biomedical Sciences East Millstone, NJ
Reliability: (1) valid without restriction
25–JUL–2000 (199)
Type: other: Effects of mixture of benzene, toluene and xylene on
liver and renal functions in rats.
Remark: Effects of the mixt. of benzene, toluene and xylene on liver
and renal functions in rats and the relationship between
these effects and lipid peroxidn. (LPO) were studied. The
results showed that the mixt. could induce defect in protein
synthesis in liver cell and inhibit the transport and
accumulation of bile acids by hepatocytes. The mixt. could
enhance the permeability of parenchymal cells when benzene
was the dominant component as detd. by measuring
glutamic–oxaloacetic transaminase (AST), glutamic–pyruvic
transaminase (ALT) and lactic dehydrogenase (LDH) in serum.
The mixt. could induce LPO in rats by subacute exposure by
measuring the contents of serum malondialdehyde (MDA), and
could inhibit the activity of serum superoxide dismutase
(SOD) and glutathione peroxidase (GSH–Px). The contents of
serum protein were neg. correlated with the contents of
serum MDA, and pos. correlated with the activity of serum
SOD. The contents of serum albumin were pos. correlated
with the activity of serum SOD and GSH–Px, the contents of
serum bile acids were neg. correlated with the activity of
serum SOD. The increase in the level of LPO and the
decrease in the activity of serum SOD and GSH–Px may
contribute to the mixt.– mediated hepatoxicity. When xylene
was the dominant, the mixt. might injure the renal function
in rats.
Appendix D: Benzene SIDS Dossier
– 782/957 –