Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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with variable degrees of benzene poisoning. The findings
from the blood studies are described.
The study shows that high benzene [usually > 320 mg/m3 (100
ppm) as TWA for months to years] may lead to marked
decrease
in white blood cell count.
Source: Deutsche Shell Chemie GmbH Eschborn
German rapporteur
Flag: Risk Assessment
13–SEP–2000 (443)
Remark: Repeated dose toxicity
This is an analysis of white and red cell counts as well as
hemoglobin of 459 benzene–exposed workers between 1940 and
1975. These workers are a subset of about 7200 rubber
workers from the Pliofilm cohort at St. Mary’s in Akron,
Ohio. Positive correlations between fluctuations in blood
count and benzene exposure were reported between 1940–1948
(mean estimated exposure = 75 ppm) but not from 1948–1975
(estimated exposure = 15–20 ppm). The authors suggest
examination of the blood is unlikely to detect
abnormalitiesat lower benzene exposures.
Source: Deutsche Shell Chemie GmbH Eschborn
German rapporteur
Flag: Risk Assessment
13–SEP–2000 (621)
Remark: Repeated dose toxicity
This report is a literature review of benzene. Topics
discussed include animal models for benzene–induced
leukemia, mechanism of benzene–induced toxicity and the
roleof benzene metabolites, studies in mutagenicity and
teratogenicity, toxicity and carcinogenicity in humans,
population exposures to benzene (especially exposure
throughwater), and risk assessment. The review is
particularly useful for historical purposes as the older
literature is included. There are 13 pages of references,
two of which goback to 1880.
Source: Deutsche Shell Chemie GmbH Eschborn
German rapporteur
Flag: Risk Assessment
13–SEP–2000 (745)
Remark: Ten workers were exposed to a benzene spill that resulted
insubstantial excretion of phenol. Three months later,
genotoxic bnormalities in peripheral lymphocytes of benzene
exposed workers and 11 controls were compared. Lymphocytes
were examined for chromosomal damage (e.g., polyploidy,
gaps, chromatid breaks, acentric fragments) and the
frequency of sister chromatid exchange. Controls had
slightly more chromosomal damage, but all values were in
thenormal range. Benzene–exposed workers had slightly more
SCEwith a slight exposure–response trend based on maximum
Appendix D: Benzene SIDS Dossier
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