Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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were approximately 1.5 to 4–fold elevated, but none were
statistically significant. There was an apparent
exposure–response trend for all LHC and qualitative
measuresof total hydrocarbon exposure, but this was not
statistically significant (p = 0.6). Analyses by workplace
showed airports had the largest incidence excess (SIR =
1006; 95% CI = 208–2940), but this was based only on 3
cases. The largest LHC excesses were observed among
workersfirst employed in the early 1960’s. Definitive
conclusions about the role of benzene and other exposures
are not possible due to the lack of quantitative exposure
data.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (204)
Remark: This study describes a case–control study of nine different
causes of death, including leukemia, nested within a single
cohort of 6678 male rubber workers. Each workers’ job was
classified into an occupational title grouping with
functionally similar jobs and exposures. No quantitative
exposure data for any exposures, including benzene, were
available. Lymphatic leukemias were found to be most
strongly associated with solvent–exposure areas, especially
inspection, finishing, and repair. However, the presence
ofmultiple chemical and physical exposures, the large
number
of different jobs held by most workers, and the lack of
quantitative exposure data preclude any definitive
conclusions regarding benzene or other exposures.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (755)
Remark: This document reviews previous concentration/effect
assessments for benzene and develops a scientific basis for
an air quality standard (AQS) on benzene. The review
findings indicate that most previous assessments have been
done using total leukemia mortality in relation to
cumulative exposure. A linear dose–response model assuming
no threshold is the most common model used. The review
concludes these assumptions likely overestimate the effects
associated with low level benzene exposures. The document
concludes that an AQS of 30 parts per billion as an annual
average is scientifically justified. This AQS is based on
acute myelocytic leukemia, which a review of the available
evidence suggests a no observed adverse effect level of 42
ppm for 1.3 years and a lowest observed adverse effect
levelof 39 ppm for 16 years for this endpoint. Several
adjustment factors to account for sensitive subpopulations
and other factors were used.
Source: Deutsche Shell Chemie GmbH Eschborn
06–JAN–1997 (232)
Appendix D: Benzene SIDS Dossier
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