Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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myelodysplastic syndrom was 7.1 (95% CI=2,1–23.7). Workers
with 10 or more years of benzene exposure had an RR of
developing non–Hodgkin’s lymphoma of 4.2 (95% CI=1.1–15.9),
and the development of this neoplasm was linked most
strongly to exposure that had occured at least 10 years
before diagnosis. The findings suggest, that recent benzene
exposure is predictive of subsequent risk for ANLL/MDS. In
contrast, recent exposure was only weakly linked to
non–Hodgkin’s lymphoma.
Cohort study (China)
Source: German rapporteur
Flag: Risk Assessment
07–JUL–2005 (486)
Remark: Chromosome analysis from peripheral blood lymphocytes of
workers after an acute exposure to benzene.
test system: chromosomal aberrations and sister–chromatid
exchanges in peripheral lymphocytes
no. of subjects: 10
expos. concentr.: not given
authors’ conclusion: negative
Source: German rapporteur (813)
Flag: Risk Assessment
07–JUL–2005 (214)
Remark: Cohort Study (USA)
Ott performed a historical cohort study (Michigan Division
Dow Chemical) on 594 individuals. In the total study
sample,
significantly more cases (n = 3) of acute non–lymphatic
leukaemia (ANLL) were observed as compared to 0.8 expected
cases (p = 0.047). However, if individuals who had been
exposed to other chemicals (e.g. arsenic, asbestos) were
excluded from the calculation of the Standardized Mortality
Ratios (SMR) seems to be unclear; neither the total
mortality nor the disease–specific mortality were
increased.
Source: German rapporteur
Flag: Risk Assessment
07–JUL–2005 (863)
Remark: Chromosome changes in patients with chronic benzene
poisoning.
test system: chromosomal aberrations and aneuploidy in
peripheral lymphocytes
expos. concentr.: not given (subjects suffered from
chronic benzene poisoning)
no. of subjects: 21
Appendix D: Benzene SIDS Dossier
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