Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
______________________________________________________________________________
reproductive performance had been revealed. A trend toward
reduced mean fetal body weights during the lactation period
and towards reduced mean organ weights (testes, liver,
kidney) on postnatal day 21 was observed at the 30 and 300
ppm level. Except for reduced body and liver weights in the
female pups at 300 ppm, these changes were not statistically
significantly different from controls. No treatment–related
effects were seen in pup survival data during lactation or
in the gross postmortem evaluation of these pups on Day 21
of lactation. Thus exposure of dams to benzene levels as
high as 300 ppm resulted in only minimal effects on the
pups.
NOAEL/rat,female: 300 ppm
Source: German rapporteur; Deutsche Shell Chemie GmbH Eschborn;
Flag: Risk Assessment
17–JUN–2005 (646)
Type: Fertility
Species: rabbit
Sex: female
Strain: New Zealand white
Route of administration: inhalation
Exposure Period: gestation days 6–19
Frequency of treatment: daily/24 hours per day
Duration of test: gestation day 29
Doses: 0.5, 1.0 mg/l; 11 and 15 rabbits respectively
Control Group: yes, concurrent no treatment
Method: other
GLP: no data
Test substance: no data
Remark: Control group consisted of 60 dams exposed to air. Dams
were killed on day 29 and foetuses examined as described by
Ungvary G. Munkavédelem, Munka–és Uzemegészségügy 29,
207–216, 1983.J. Hyg. Epidem. Microbiol. Immun. 24, 363–371,
1980.
Result: The top dose caused statistically significant decreases in
maternal weight gain and mean foetal weight and a
statistically significant increase in the number of dead or
resorbed foetuses, mainly arising from abortion. At 0.5
mg/l, a slight non–significant decrease in maternal weight
gain and increase in the number of dead or resorbed foetuses
was reported.
Source: BP Chemicals Ltd LONDON
17–OCT–2000 (1190)
Appendix D: Benzene SIDS Dossier
– 564/957 –