Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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Species: mouse Sex: female
Strain: Swiss Webster
Route of administration: inhalation
Exposure period: gestation days 6–15
Frequency of treatment: daily/6 hours per day
Duration of test: 2–day–old neonates
Doses: 5, 10, 20 ppm/day (converts to 0.017, 0.033, 0.066
mg/l/day); 5–10 mice/dose
Control Group: yes, concurrent no treatment
Method: other
GLP: no data
Test substance: no data
Remark: Control group consisted of five to ten females exposed to
filtered conditioned air. Exposed, pregnant mice were
allowed to proceed through normal parturition. Two male and
two female neonates/litter were selected at 2 days of age,
weighed and examined for any external gross morphological
malformations. Livers were removed for enumeration of
haematopoietic colony forming cells.
Result: No difference in CFU–E numbers were noted between the
low–dose offspring and the controls. Offspring exposed, in
utero, to 0.033 mg/l had either increased or decreased CFU–E
numbers and those in male offspring exposed in utero to
0.066 mg/l were increased. The numbers of
granulocytic/macrophage colony forming cells were increased
in the male and female offspring from the top–dosed group
and decreased in the male offspring in the mid–dosed group.
Source: BP Chemicals Ltd LONDON
25–OCT–2000 (607)
Species: mouse Sex: female
Strain: Swiss Webster
Route of administration: inhalation
Exposure period: gestation days 6–15
Frequency of treatment: daily/6 hours per day
Duration of test: 6–week–old offspring
Doses: 5, 10, 20 ppm/day (converts to 0.017, 0.033, 0.066
mg/l/day); 5–10 mice/dose
Control Group: yes, concurrent no treatment
Method: other
GLP: no data
Test substance: no data
Remark: Control group consisted of five to ten females exposed to
filtered conditioned air. Exposed, pregnant mice were
allowed to proceed through normal parturition. At 6 weeks
of age, one male and one female offspring were selected from
each litter, sacrificed and their spleens and femurs removed
for enumeration of haematopoietic colony forming cells.
Result: CFU–E numbers were equivalent to the control values except
in the males exposed to 0.033 mg/l in utero which displayed
significant variations from the controls.
Source: BP Chemicals Ltd LONDON
25–OCT–2000 (607)
Appendix D: Benzene SIDS Dossier
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