Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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Species: rat Sex: male/female
Strain: Wistar
Route of administration: inhalation
Exposure period: up to 212 days
Frequency of treatment: 7 hours per day/5 days per week
Post exposure period: 18–22 hours
Doses: 0.28, 7, 14, 21, 30 mg/l; 10–25 rats/sex/dose
Control Group: yes, concurrent no treatment
NOAEL: < .28 mg/l
LOAEL: = .28 mg/l
Method: other
GLP: no data
Test substance: other TS
Remark: Groups of ten to 25 male and female animals were used.
All animals were weighed at regular intervals during the
study and frequent observations made of their general
appearance and behaviour. Records were kept of food
consumption and mortality. The gross appearance of the
lungs, heart, liver, kidneys, spleen and testes was observed
and these organs weighed. Histopathological examination of
these organs and the adrenals, pancreas and femoral bone
marrow was made. Blood was collected from selected animals
of each group at autopsy.
TS concentration was analysed (no data about method) and
adjusted, variation of concentration 10%. Males and females
tested only at the low dose, other groups only males.
Result: Increased spleen weight and unspecified changes in blood
histopathology including leucopenia were recorded at the
lowest dose level with, in addition, narcosis, growth
depression and unspecified spleen and bone marrow
histopathology at 7 mg/l (exposure period 221 d) or more (up
to 93 d). Mortality rate increased at >= 14 mg/l and
increased testis weight and unspecified liver histopathology
occurred at 21 mg/l (exposure period 93 d).
Source: BP Chemicals Ltd LONDON
Deutsche Shell Chemie GmbH Eschborn
Test substance: 99.98% pure.
06–JUL–2005 (1263)
Appendix D: Benzene SIDS Dossier
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