Appendix D - Dossier (PDF) - Tera

date: 20–JUL–2005
5. Toxicity Substance ID: 71–43–2
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Type: Cytogenetic assay
Species: mouse Sex: male/female
Strain: CD–1
Route of admin.: inhalation
Exposure period: 13 weeks
Doses: 0, 1, 10, 30, 300 ppm (converts to 0, 0.003, 0.033, 0.098,
0.98 mg/l0
Method: other
GLP: no data
Test substance: no data
Remark: Report of a study conducted for the American Petroleum
Institute.
Result: No increase in chromosomal damage was observed at
concentrations of 0.098 mg/l or below. Slight increases in
aberrations were seen at 0.98 mg/l but these were only
statistically significant in the females.
Source: BP Chemicals Ltd LONDON
13–DEC–1996 (321) (491)
Type: Cytogenetic assay
Species: rat Sex: male
Strain: Wistar
Route of admin.: i.p.
Exposure period: single dose
Doses: 878 mg/kg bw
Method: other
GLP: no data
Test substance: other TS
Remark: Groups of five male Wistar–derived, outbred, Alderely Park
rats were injected with benzene or, in the case of the
control group, water. The animals were killed 24 hours
later, the bone marrow samples prepared according to the
method of Sugiyama T. J. natn. Cancer Inst. 47, 1267–1275,
1971 but with slight modifications and the slides examined
for any chromosome abnormalities.
Result: Benzene caused a statistically significant increase in the
numbers of cells with abnormalities and chromatid and
chromosome gaps and breaks.
Source: BP Chemicals Ltd LONDON
Test substance: Laboratory reagent grade; purity not specified.
13–DEC–1996 (31)
Appendix D: Benzene SIDS Dossier
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