point uncertainty factors with distributions derived from empirical data <strong>for</strong> sets ofchemicals and endpoints that are putatively analogous to the chemical and biologicalresponse being considered <strong>for</strong> standard setting. This paper first reviews past experiencein the application of a “Straw Man” system developed to accomplish theseobjectives. It then uses this system to create a value of in<strong>for</strong>mation framework <strong>for</strong>evaluating the amount of reduction in uncertainty obtainable from different in vitroand in vivo tests‚Äîquantifying the reduction in uncertainty in expected risks obtainedafter adding progressively sophisticated and expensive types of toxicological in<strong>for</strong>mation.An initial illustration uses correlations between in vitro measures of chemicalpotency <strong>for</strong> different endpoints (AC50’s) with more familiar LOAEL potency data.M2-H.3 Hawkins NL, Kirson A, Levine ES, Susel I, Szwed P, Waters J; natasha.hawkins@dhs.govUS Department of Homeland Security, Office of <strong>Risk</strong> Management and <strong>Analysis</strong>, US CoastGuardUSING EXPERT JUDGMENT TO UNDERSTAND THE RARE EVENTTHREAT SPACE OF HOMELAND SECURITY: PRACTICES, CHAL-LENGES, AND OPPORTUNITIESThe Department of Homeland Security (DHS) manages risks to the Nationarising from such threats as terrorism, natural and manmade disasters, cyber attacksand transnational crime. The nature and unpredictability of acts of terrorism presentunique challenges. DHS per<strong>for</strong>ms separate biennial Terrorism <strong>Risk</strong> Assessments(TRAs) <strong>for</strong> chemical (CTRA) and biological (BTRA) threats as required by HomelandSecurity Presidential Directives (HSPDs) 22 and 10, respectively. DHS also per<strong>for</strong>msan Integrated Terrorism <strong>Risk</strong> Assessment (ITRA), mandated by HSPD 18, which incorporates,integrates and expands upon the BTRA and CTRA and establishes similaranalyses <strong>for</strong> radiological and nuclear threats (RNTRA). In addition, the Department’s<strong>Risk</strong> Assessment Process to In<strong>for</strong>m Decision-making (RAPID), in support of theDHS Policy <strong>for</strong> Integrated <strong>Risk</strong> Management (May 27, 2010), provides an all-hazardsrisk analysis by incorporating the in<strong>for</strong>mation from all of these TRAs and addressesadditional risks such as those from natural disasters and other threats. All of theseanalyses are probabilistic risk assessments. Due to the rare event nature of many ofthese threats and/or the scarcity of data, some of the key inputs <strong>for</strong> the TRAs andRAPID have been elicited from the intelligence community and program experts.These inputs have a very high degree of unavoidable uncertainty. To obtain thesejudgments DHS has adapted an expert elicitation process originally developed <strong>for</strong>the nuclear power sector. This presentation will describe how that elicitation processhas been adapted by DHS, and discuss the state of the science as it relates to elicitationof judgment <strong>for</strong> rare or highly uncertain events in key areas such as: de-biasing,quantifying and handling uncertainty, relative versus absolute judgments, treatment114of conflicting results from multiple experts, and validation. The presentation will put<strong>for</strong>th a research agenda to contribute toward progress in these key areas.M3-J.2 Hawkins B, Shroy B, Montello B, Gooding R, Kolakowski J, WhitmireM, McGarvey D; rachel.gooding@associates.dhs.govBattelle Memorial Institute, DHS Chemcial Security <strong>Analysis</strong> CenterCHEMICAL INFRASTRUCTURE RISK ASSESSMENTThe Department of Homeland Security’s Chemical Security <strong>Analysis</strong> Center(CSAC) is responsible <strong>for</strong> the science based knowledge and characterization of chemicalrisk to the nation. The CSAC has completed the first phase of the Chemicalinfrastructure <strong>Risk</strong> Assessment, a study of the acute risk to human health and thenational economy due to a terrorist initiated event within the chemical supply chain.The probabilistic risk assessment, which examines 46 toxic industrial chemicals, considersdifferent types of terrorist groups with varying levels of financial and technicalresources, multiple attack modes and target types. The targets include various featureswithin a chemical facility such as storage vessels, process units, process controlsystems, etc as well as transportation modes such as rail, bulk and non-bulk highway,barges and pipelines. The study was based on a comprehensive synthesis of Departmentof Homeland security chemical facility location data, GIS population data,and GIS data <strong>for</strong> rail lines, roadways and navigable waterways along with an extensivedataset to provide location specific meteorology to produce an accurate estimate ofconsequences. The impacts of security and mitigation features were also includedin the analysis, as well as the distinction between insider and outsider threats and thelikelihood of interdiction. The baseline study, as well as evolving sensitivity studiescan be used to understand the main contributors of risk from the US chemical supplychain, where the greatest impacts can be achieved, as well as areas where there appearto be diminishing returns with additional ef<strong>for</strong>ts to buy down risk.P.102 Hawks C, Waller R*; rw@protectheritage.comProtect Heritage Corp.A TALE OF TWO SYSTEMS: SYNERGY IN MANAGING RISKS TO PEO-PLE AND TO MUSEUM COLLECTIONSThe two systems of managing health and safety and of managing preservationof cultural property have many parallels. Either, or both, can exist as predominantlyhabit-based systems. However, when managed from a proactive perspective, they canbe considered goal-directed systems. In the first case, the goal is to maintain healthand avoid accidents to people. In the second case, the goal is to avoid damage and lossto cultural property. Both goals are clear, widely accepted, and even in-arguably nobleand worthy, seemingly a great advantage <strong>for</strong> both systems. However, this in-arguablegoodness of the goals can lead to unquestioned, habit-based systems rather than rational,strategic approaches. Habit-based and goal-based approaches are not mutuallyexclusive. A well-managed goal-based system will foster adoption of good habits that
then allow both systems to operate as effectively and economically as possible. Bothhealth and safety and cultural property preservation systems will operate best whenthey are mutually supportive. In many instances, this mutual support arises automaticallyas a consequence of the basic similarities of the systems—both strive to avoidany unnecessary and harmful interaction of people, energy and materials. Examplesof natural alignment, potentials <strong>for</strong> better alignment, and conflict between the twosystems are given through cartoon depictions. Viewing health and safety and culturalproperty preservation as parallel and closely related risk management systems opensthe way to improvements in both. Combining the two encourages synergies that canlead to effective risk management and resource allocation by custodians of our collectedheritage.T2-H.3 Hawks ES, Burns JM, Bowdle DA, Middleton JK; middletonj@battelle.orgBattelleUPDATING DATA FOR THE DEPARTMENT OF HOMELAND SECU-RITY’S BIOTERRORISM RISK ASSESSMENTHomeland Security Presidential Directive 10 (HSPD-10), titled Biodefense <strong>for</strong>the 21st Century, identified the need <strong>for</strong> a rigorous and technically sound methodology<strong>for</strong> assessing the bioterrorism risk to the nation. In response, the Departmentof Homeland Security (DHS) Science and Technology Directorate developed theBioterrorism <strong>Risk</strong> Assessment (BTRA). By definition, the attack scenarios in theBTRA model involve biological agent production, subsequent bioagent dispersion,and the potential <strong>for</strong> public health consequences. A large set of bioagent specific datais required to facilitate modeling of these scenarios. To ensure that the best availablescience and expert judgments are used in the assessment, the data are periodicallyupdated through comprehensive review of the published scientific literature, governmentreports, and interactions with relevant Subject Matter Experts (SMEs). Presentedhere is a summary of the data update ef<strong>for</strong>ts per<strong>for</strong>med following submissionof the 2010 BTRA report. These ef<strong>for</strong>ts included an extensive data collection ef<strong>for</strong>tand review of the data by SMEs from across academia, industry, and the government.The impact of the ~1,200 additional references reviewed <strong>for</strong> the 38 biological agentscurrently considered in the BTRA along with the over 500 input datasheets reviewedby SMEs are summarized. Knowledge areas in which the literature and SME inputcontinue to show the need <strong>for</strong> additional research ef<strong>for</strong>ts will also be discussed.W2-G.2 Hays S, Kirman C, Aylward L; shays@summittoxicology.comSummit ToxicologySOURCES OF VARIABILITY IN BIOMONITORING DATA: TEMPO-RAL VARIATION IN SPOT SAMPLE CONCENTRATIONSConventional external dose exposure assessments (e.g., measuring chemicals inair, water, food, soil, consumer products, etc. and assuming intake/contact rates to estimateaverage and peak intake of a chemical) are increasingly being supplemented orsupplanted by internal dose-based assessments using biomonitoring data. However,biomonitoring studies generally rely upon single spot urine samples or single bloodsamples. This provides, at best, a snapshot in time of the concentrations of chemicalsin a particular person, which may be difficult to interpret <strong>for</strong> short-lived chemicals.For most chemicals, understanding chronic average exposures is more relevant torisk assessment. Understanding how chemical concentrations in spot urine or bloodsamples compare to ‘average’ chemical concentrations in people’s (individuals andpopulation) blood and/or urine is critical to assessing chemical-specific public healthrisks. While numerous sources of variability in spot samples exist (magnitude ofexposure, pharmacokinetics and temporal variability), this presentation focuses onthe issue of temporal and inter-individual variability. By understanding the factorsthat govern temporal variability in chemical concentrations, researchers can betterunderstand how to design biomonitoring studies and interpret individual and populationdistribution biomonitoring data. This presentation explores recent datasets <strong>for</strong>phthalates and BPA concentrations in spot samples in individuals over time. Thesedata improve our understanding of the factors governing variation in levels of thesecompounds in blood and urine within a day, across days and across individuals. Datasets<strong>for</strong> numerous other compounds (metals, PAHs, etc.) help in<strong>for</strong>m the chemical-(e.g., half-life) and exposure source-specific (frequency and route of exposure) factorsthat govern the degree of variability that might be expected <strong>for</strong> a given compound.W3-H.3 He F, Zhuang J, Rao NSV; jzhuang@buffalo.eduUniversity at Buffalo, Oak Ridge National LaboratoryATTACKER-DEFENDER GAMES IN CYBER-PHYSICAL NETWORKSA number of critical network infrastructures rely on cyber and physical componentsthat are both subject to natural, incidental or intentional degradations. In thispaper, the strategic interactions between an attacker and a defender of such infrastructuresare studied using a sequence of game theoretic models. We <strong>for</strong>mulate thecyber-physical infrastructure problems as games between an attacker and defenderattempting to optimize individual utilities consisting of the sum of costs and systemgains. The probability of a system’s survival is a function of both the attackers’ anddefenders’ options: (a) binary options correspond to attacking/defending entire cyberand physical parts; and (b) discrete options correspond to attacking/defending a numberof cyber and physical components. Nash equilibrium and subgame-perfect Nashequilibrium strategies are derived <strong>for</strong> the simultaneous-move and sequential-movegames, respectively. Both analytical and numerical results were provided to illustratethe models. <strong>Final</strong>ly, simulation results of cloud and high-per<strong>for</strong>mance computing examplesare presented to complement the analytical results. Our results provide insightinto the survival of such infrastructures under various costs and the knowledge thatplayers have of the infrastructure and each other.115
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Workshops - Sunday, December 4Full
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WK9: Eliciting Judgments to Inform
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These freely available tools apply
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Plenary SessionsAll Plenary Session
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M2-C.1 Abraham IM, Henry S; abraham
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SECOND FLOOR Floor MapConvention Ce