choice experiment questionnaire to measure attitudes among US wildland fire managerstoward several sources of risk. It represents one of the first stated choice studiesto incorporate probability weighting, which allows <strong>for</strong> nonlinear effects of probabilityon utility. Results provide a means <strong>for</strong> comparisons among wildfire managers’ riskpreferences and the risk preferences of professionals in other fields. Additionally, wedemonstrate that the efficiency of fire management over repeated wildfire events canbe improved through decision environments that allow <strong>for</strong> and encourage reducedrisk aversion among managers.W2-E.1 Callahan J, Dennis S; julie.callahan@fda.hhs.govFood and Drug Administration, Center <strong>for</strong> Food Safety and Applied NutritionRISK ANALYSIS DURING FOOD SAFETY EMERGENCIESConducting risk assessments, making risk management decisions and communicatingrisk during urgent food safety incidents with serious public health implicationspose unique challenges <strong>for</strong> risk analysis professionals. Each food safety incidentor emergency is likely to be unique in terms of the nature of the incident as well asthe amount and quality of in<strong>for</strong>mation available and there<strong>for</strong>e may need to be approachedon a case-by-case basis. However, robust methods <strong>for</strong> conducting risk assessmentsand making risk management decisions, regardless of the level of pressureassociated with a particular food safety incident or emergency are critical to ensurethat timely decisions are based on a logical and knowledgeable understanding of thesituation rather than an emotional (or intuitive) basis. This presentation will focuson the US FDA participation in work to develop the FAO/WHO guide <strong>for</strong> applicationof risk analysis during food safety emergencies, including outcomes and lessonslearned from this project.T2-G.3 Calle JJ, McGill WL; jjc5111@psu.eduThe Pennsylvania State UniversitySORTIT - AN ONLINE MULTIPLAYER ADVENTURE GAME FORPAIRWISE RANKING OF RISKSWe present the design and evaluation of a serious online browser game calledSortIT <strong>for</strong> eliciting pairwise comparisons of risks. SortIT is a two-player collaborativegame that rewards players depending on whether they match the responses oftheir partner (i.e., an output-agreement game). Each round of SortIT presents playerswith a choice. Such choices include an assessment of which of two risks is moreor less risky, whether a risk is considered voluntary or involuntary, etc. SortIT is builtatop of an adventure game plat<strong>for</strong>m - in the game, players work together to defeat aseries of monsters in a dungeon. The goal is to defeat the monsters and move on tothe next dungeon. Each correct response (e.g., both players agree on the same risk asbeing more risky among the two presented to them) produces a hit on the monster,whereas an incorrect match results in the monster hitting the players. A successfulkill of the monster may yield treasures such as weapons and protective armor. In our72initial test of SortIT, we considered an array of cyber-oriented risks and a full set ofpsychometric dimensions thought to influence perceptions of these risks. Our resultsenabled us to display how individuals and groups playing the game rank order a set ofrisks and how they label individual risks. Players found the experience playing SortITto be very fun to the point where they expressed disappointment about having tostop when the experiment was over. In this talk, we present the full details of SortIT,including game design, concept, test, and results. Future directions are also discussed.M4-D.5 Cammarata C; cammarac@ctc.comConcurrent Technologies CorporationMETHODOLOGY FOR USING LIFE CYCLE ASSESSMENT TO MINI-MIZE ENVIRONMENT, ENERGY, WATER, AND CHEMICAL LIABIL-ITIESDomestic and <strong>for</strong>eign policies (i.e., EO 13514, REACH and RoHS) have placedpressure on the U.S. Department of Defense (DoD) to implement more sustainablepractices <strong>for</strong> weapon system acquisition. As part of its sustainability ef<strong>for</strong>ts,the DoD seeks to use Life Cycle Thinking (LCT) to ensure that decisions regardingweapon system design consider potential impacts to human health and the environmentacross the system’s life cycle. To guide this ef<strong>for</strong>t, commonly-used Life CycleImpact Assessment (LCIA) methods and the components of those methods (e.g.,impact categories, metrics, characterization factors, weighting mechanisms) were reviewedand summarized with regard to their applicability to DoD’s LCT ef<strong>for</strong>ts. Gapsidentified included the absence of assessment methods <strong>for</strong> quantifying potential impactsto worker health and site-specific weighting mechanisms. This presentation willhighlight the current progress toward resolving these challenges and the unique considerationsthat large government institutions, such as the DoD, face when embracingLCT. This presentation also will present the current state of the life cycle impactassessment methodology being proposed.W2-D.2 Camp JS, Abkowitz MD, Hornberger GM; janey.camp@vanderbilt.eduVanderbilt UniversityCLIMATE CHANGE IMPACTS ON FREIGHT TRANSPORTATION IN-FRASTRUCTURE - ADAPTATION STRATEGIES AND CHALLENGESOne key aspect of our livelihood that is threatened by climate change is the integrityand per<strong>for</strong>mance of our freight transportation systems. In the U.S., the freighttransportation network is a complex mosaic of highways, railroads, waterways, airportsand pipelines, covering millions of miles and involving interactions at thousandsof terminals. Sufficient climate changes are and will be taking place that requirean adaptive response. Potential changes of interest include warmer temperatures,sea level rise, more frequent and violent storms, and greater weather extremes. Theimpacts of these changes can range from imposing minor delays in the delivery ofgoods to the consumer, to rendering entire regions of the country impassable <strong>for</strong> long
periods of time. Successful adaptation can be achieved by reducing vulnerability (susceptibilityto adverse effects of climate change) or by enhancing resilience (capabilityto survive climate-induced events with minimal damage). The focus of this paper ison the per<strong>for</strong>mance of transportation infrastructure in the face of a changing climate.Three fundamental questions are examined: (1) at what climate change thresholds willfreight transportation adaptation be necessary, (2) what types of adaptation strategieswould be most responsive to societal needs under these circumstances, and (3)what is a sensible path <strong>for</strong>ward in terms of in<strong>for</strong>mation and research needs, strategicinitiatives and short-term actions that will enable us to be better prepared to addressthese considerations? These questions are addressed in the context of various climatescenarios. Highlighted in the discussion are the challenges of both decision makingunder uncertainty associated with the limitations of currently available in<strong>for</strong>mation toassess scenario likelihood and consequences and evaluation of the benefits and costsof candidate adaptation strategies. Findings from a national summit recently hostedby the authors are used as a resource in addressing these challenges.P.66 Campbell, Jr. JL, Andersen ME, Kim D, Yi KD, Pastoor T, BreckinridgeCB, Clewell, III HJ; jcampbell@thehamner.orgThe Hamner Institutes, RTP, NC, Syngenta, LLCPBPK MODELING WITH ATRAZINE: SIMULATION OF THE DY-NAMIC CHANGES IN AN IN VITRO SYSTEM TO SUPPORT IN VITROTO IN VIVO EXTRAPOLATION ACROSS SPECIESA published PBPK model <strong>for</strong> atrazine (ATZ) in rats (McMullin et al., 2007)was expanded with new time-intensive pharmacokinetic data collected from femaleSprague Dawley rats (Kim et al., 2011) and cynomolgus monkeys (Yi et al., 2011).Partition coefficients, measured by in vitro equilibration or estimated with QSARmethods, were validated against tissue concentration measurements from in vivo studiesin rodents. Phase I metabolism of ATZ including the generation and clearance ofdesethyl ATZ (DEA), desiso ATZ (DIA) and di-dealkylated, diaminochlorotriazine(DACT) was studied in whole rat and human hepatocyte suspensions. Phase II metabolismwas characterized in the cytosolic fractions from Sprague-Dawley rat, cynomolgusmonkey and human liver. A one compartment model was developed <strong>for</strong>the hepatocyte incubations. The ability to incorporate in vitro metabolic parametersfrom the in vitro test system to the in vivo PBPK model was greatly improved byincluding competitive inhibition of metabolism among ATZ, DEA and DIA and byadjusting the number of viable hepatocytes in the system by the reported time-variantviability. Metabolic parameters from this in vitro model were incorporated into thePBPK model by scaling based on the hepatocellularity of the liver. Prediction of thetime-course disposition and elimination of ATZ and the chlorotriazine metabolitesacross the dosing regimens and the range of doses <strong>for</strong> rat, monkey and human wereimproved with the incorporation of the metabolic rates derived from the in vitro systemsinto the in vivo PBPK model. This extended PBPK model can predict plasmatime-course and urinary elimination data <strong>for</strong> ATZ and the chlorotriazine metabolitescollected in rats, monkeys and humans after intravenous, oral or dietary exposure toATZ. The PBPK model can also characterize pharmacokinetic differences acrossspecies and dose levels and support a human risk assessment based on internal dose.P.1 Cantor RA, Menzie CA, Deardorff TL, Hulme-Lowe CK, WickwireWT; rcantor@exponent.comExponentSEEING THE FOREST THROUGH THE TREES: NRD AND DYNAM-IC ECOSYSTEMSUnder certain federal and state statutes, public agencies can claim economicdamages resulting from injuries to natural resources. The principles <strong>for</strong> estimatingthe reduced value of services provided by natural resources are similar to those <strong>for</strong>estimating damages associated with any resource or asset. An important source of debateand uncertainty about these estimates, however, is whether there are net losses inecological services following man-made disturbances that mimic natural disturbances.Ecological processes include photosynthesis, energy flow, nutrient cycling, watermovement, disturbance, and succession. Disturbances such as wildfire, floods, orwindthrow are natural and integral processes in many systems. Organisms that makeup the biotic component of such systems have evolved in response to environmentalchanges triggered by disturbances. Disturbances often move ecosystems towardsearlier successional stages, stimulating renewal processes and short-term increases inproductivity. Large-scale disturbance may move an ecosystem to a new system statefrom which it may, or may not, return to its predisturbance condition. Measuring thenet change in ecosystem resources and services and the resulting natural resourcedamages (NRD) is complicated by the positive ecosystem benefits that large-scaledisturbances often provide. In recent litigation, public agencies have used valuationmethodologies <strong>for</strong> NRD that attempt to simplify the analysis by associating damageswith the loss of some countable resource such as fire-killed trees. We show in thecase of wildfires that this approach fails to recognize the dynamics of the ecosystemservices and in specific circumstances, grossly overestimates the damages from thedisturbance. Our analysis indicates that in order to properly value ecological baselineand recovery from disturbances that mimic natural processes, the NRD frameworkmust reflect not only levels of ecosystem services, but also their dynamics.P.121 Caton BP, Miller CE, Jang EB; barney.p.caton@aphis.usda.govUSDA-APHIS, Consultant, USDA-ARSQUANTIFYING AN EXAMPLE SYSTEMS APPROACH USED TO MITI-GATE THE RISK OF ESTABLISHMENT OF FRUIT FLIESWe used a probabilistic model to investigate how an example systems approachmay be used to mitigate the risk of establishment of fruit flies via imported fruit <strong>for</strong>consumption. In this example, we considered an import scenario with the following73
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These freely available tools apply
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SECOND FLOOR Floor MapConvention Ce