serious accident of the Tokyo Electric Power Company’s Fukushima Plant. Someopinion polls carried out by Newspaper companies in April and May showed thatthe percentage of support <strong>for</strong> Japan’s nuclear power generation become lower thanbe<strong>for</strong>e, but still higher than those of European survey results, such as a result <strong>for</strong>mthe Cardiff University. (We are going to submit on-going survey, but we thought itis important <strong>for</strong> us and other members of SRA to know and consider about Japan’scurrent crisis as early as possible.).W1-H.1 Apivatanagul P, Davidson RA, Nozick LK, Wachtendorf T; rdavidso@udel.eduUniversity of Delaware, Cornell UniversityRISK-BASED REGIONAL HURRICANE EVACUATION PLANNINGRegional hurricane evacuation involves moving thousands of people with differentneeds from a wide geographic area in only a few days under uncertain, dangerousconditions, getting them to safe locations, and keeping them safe until theyreturn. It is an extraordinarily complicated process and the stakes are high. Despitegreat progress, recent events and unchecked population growth in hurricane-proneregions make it clear that challenges remain. The traditional, appropriately conservativeapproach of evacuating everyone thought to be at risk is no longer feasible inmany areas where there are just too many people and too little transportation capacity.In the past, math modeling in this application has been limited to estimating the timerequired to clear a region. In this paper we introduce a new approach that reframesthe problem more broadly. By refocusing on the true objectives of minimizing riskand cost, this new decision frame allows direct integration and comparison of new alternativeslike sheltering-in-place and phased evacuation. It considers the uncertaintyin hurricane track and intensity explicitly so we can pursue a strategy that is good onaverage but also robust so that the impact is not terrible no matter how the hurricaneevolves. Specifically, we present a new bi-level optimization model developed to helpguide: (1) who should evacuate and (2) when. The upper-level develops the evacuationplan and the lower-level is a dynamic traffic assignment model that evaluates theproposed plan in terms of the resulting expected risk and travel times across all possiblehurricane scenarios. The model iterates between the levels until they converge.To demonstrate the model, we present a regional case study <strong>for</strong> North Carolina thatincludes the recommended plans under different assumptions about which scenariosare possible. We compare the resulting per<strong>for</strong>mance <strong>for</strong> each plan in terms of risk andtravel times <strong>for</strong> different actual hurricane scenarios.56W3-A.4 Austin LC; lau.lpf@cbs.dkCopenhagen Business SchoolSAME TEST, SAME RESULT - SAME INFORMATION? A STUDY OFPHYSICIAN AND LAY UNDERSTANDING OF MEDICAL TESTS ANDRISKIncreasingly, technology offers ways to screen asymptomatic people <strong>for</strong> undetectedconditions or risks of future conditions, imposing new demands on doctorsand patients in terms of understanding risk and risk management. An important butsometimes underappreciated difference between diagnosis of symptomatic peopleand screening of asymptomatic people is the fact that different prevalence rates (i.e.,prior risk) in two groups can lead to dramatically different positive predictive values(PPV = probability a positive result is a true positive) given the same test and apositive result. This arises because the prevalence of a condition in a symptomaticpopulation is generally higher than in the overall population. Intuitively, it can bedifficult to comprehend that the same test, with the same positive result, can havevery different meanings <strong>for</strong> different people. This work examines 59 Scandinaviangeneral practitioners’ and 44 international MBA students’ understanding of this <strong>for</strong>mammography, which is routinely used <strong>for</strong> screening and diagnosis. In written surveys,two women who had positive mammogram test results were described. Theywere essentially identical (in age, work environment, family history), but one had amammogram as part of a mass screening program, and the other because of a lumpin her breast. GPs estimated breast cancer prevalence in the general screening populationand among symptomatic women, and the probability each result was a true orfalse positive. MBAs estimated the probability each woman truly had cancer given apositive test. Half of the MBAs wrongly believed the two women were equally likelyto actually have cancer, suggesting many intuitively do not understand the differencebetween screening and diagnosis. Only 10% of GPs responded that the PPVs arethe same, but they underestimated the magnitude of the difference. These and otherresults are discussed.M4-H.4 Austin T, Sageman M, Luckey T, Cameron J; tom.austin@boeing.comThe Boeing CompanyADAPTIVE ADVERSARY AGENT-BASED MODELING FOR CBRNTERRORISM RISK ANALYSISAn agent-based methodology framework has been developed to model thebehavior, decision making, and asymmetric tactics, techniques and procedures ofan intelligent, adaptive and reactive adversary planning, preparing to execute an attackusing chemical, biological, radiological or nuclear weapons of mass destruction(WMD). WMD terrorist attack likelihoods and risk assessments will be modeled byadaptive learning computer software agents who operate in a virtual world and followplanned and contingency-based rule sets that adapt to the defender’s world. The
model framework is built on the cornerstone of the Observe, Orient, Decide andAct Loop process. This methodology was developed <strong>for</strong> the Department of HomelandSecurity Science & Technology Directorate requirement to build new terrorismrisk analysis applications that provide the estimation of attack likelihoods and attackmodes of potential terrorist WMD attacks against the U.S.T4-C.3 Aylward LL, Hays SM, Kirman CR, Becker RA; laylward@summittoxicology.comSummit Toxicology, LLPRISK ASSESSMENT OF EXPOSURE TO TRIHALOMETHANE DRINK-ING WATER DISINFECTION BY-PRODUCTS. USE OF BIOMONITOR-ING EQUIVALENTS AND BIOMONITORING DATA FROM NHANESThis case study explores the application of the Biomonitoring Equivalents (BE)paradigm and population-representative biomonitoring data <strong>for</strong> THMs in blood fromthe National Health and Nutrition Examination Survey (NHANES) to risk assessmentof non-cancer endpoints <strong>for</strong> THMs. BEs provide a translation of existing riskassessment exposure guidance values such as reference doses (RfDs) or risk-specificdoses into estimates of equivalent biomarker concentrations using available pharmacokineticdata or models. BE values can be used to provide a screening level assessmentof chemical biomonitoring data such as that generated by NHANES in thecontext of the current risk assessments. Biomonitoring data provide an integratedreflection of exposure from all routes and pathways of exposure. Because THMs arerapidly absorbed and eliminated, issues in interpretation of biomonitoring data associatedwith the transience of the biomarker are discussed. This case study exploresalternative approaches <strong>for</strong> low-exposure extrapolation of risk of non-cancer hepaticoutcomes from THM exposure in the general US population based on the NHANESbiomonitoring data and the BE approach. The approaches used here con<strong>for</strong>m to theIPCS framework <strong>for</strong> risk assessment of combined exposures to multiple chemicals(Meek et al. 2011). Specifically, this case study examines combined exposures (as reflectedin population-representative biomonitoring data) to a group of chemicals thatshare common structural elements, common exposure sources, pathways, and characteristics,common target organ and toxic response, and probably, a shared modeof action. For this case study, dose addition is assumed, and a hazard quotient andindex approach is applied. Alternative methods of low-dose extrapolation are alsoexamined.T4-D.1 Ayre KK, Summers HM, Landis WJ; kim.kolb@wwu.eduWestern Washington UniversityTHE USE OF A BAYESIAN NETWORK FOR THE CALCULATION OFECOLOGICAL RISK FOR HG CONTAMINATION IN THE SOUTHRIVER, VAHistoric industrial activities in Waynesboro, Virginia from 1929 to 1950 resultedin mercury contamination of the South River. Despite the time that has elapsed fromthe mercury release, mercury concentrations in the river, fish and wildlife remain.The role of this landscape-scale ecological risk assessment was to assess the potentialimpacts of mercury and other stressors to fish and wildlife, and provide a modelingframework to evaluate the effects of different environmental management scenariosto support restoration of the watershed. The results presented in this talk will focuson risk evaluation <strong>for</strong> smallmouth bass populations in the South River extendingfrom the watershed upstream of Waynesboro to the confluence of the South Riverwith the North River and Shenandoah. Sources of stressors in the watershed include:mercury contaminated sites, stream modification, discharges, effluents, run-off,recreational activities and land uses such as agriculture and residential development.The structure of the risk assessment is based on that of the relative risk model butwith a Bayesian network being used to calculate risk and uncertainty. The Bayesiannetwork reflects causal pathways, incorporates a broad array of data available <strong>for</strong> thesite, and includes the results of opinions solicited from experts. The results suggestthat mercury contamination is not the only factor that is impacting the populationsof smallmouth bass in the South River, and restoration of the watershed will requiremore than removal of mercury from the system.W4-D.2 Balch MS; michael@ramas.comApplied BiomathematicsRECENT ADVANCES IN PROBABILITY-BOUNDS THEORY APPLIEDTO AEROSPACEThe practice of segregating aleatory and epistemic uncertainty has gained recenttraction in the aerospace engineering community. Under this approach, aleatoryuncertainty is still represented probabilistically, but epistemic uncertainty sometimesis represented using intervals. When propagating mixed <strong>for</strong>ms of uncertainty, it isnecessary to express answers in terms of probability bounds statements. The statementscan be represented using p-boxes, credal sets, or Dempster-Shafer structures.A number of recent discoveries concerning probability-bounds methods have beenmade. The first concerns application of these methods to the problem of quantifyinguncertainty in the Mars atmosphere density profiles due to uncertainty in dust levels.It was found that probability-bounds methods not only yield more defensible results,but results that supported confidence intervals that were twice as wide as would beobtained using a purely probabilistic maximum entropy approach. Secondly, it has57
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